A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors - sprookjes - yvandenbroek - TriplyDB

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

http://www.wikidata.org/entity/Q24564011

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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase In vivo bio-imaging using chlorotoxin-based conjugates Wnt/beta-catenin signaling and small molecule inhibitors Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer Mouse models for the discovery of colorectal cancer driver genes Mouse models of intestinal cancer Colorectal cancer models for novel drug discovery Understanding phenotypic variation in rodent models with germline Apc mutations Animal models of colorectal cancer Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model APC-dependent suppression of colon carcinogenesis by PPARgamma Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity Loss of adenomatous polyposis coli gene function disrupts thymic development Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice Essential role of beta-catenin in postnatal bone acquisition A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.Mouse models of colorectal cancer.p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation Murine models of colorectal cancer.Insights into cancer from transgenic mouse models.Bacterial oncogenesis in the colon Mouse models for colorectal cancer.Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.Genetic and Chemical Models of Colorectal Cancer in Mice.

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P2860

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

http://www.wikidata.org/entity/Q24564011

description

1994 nî lūn-bûn

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1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年论文

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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A targeted chain-termination m ...... in multiple intestinal tumors

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P2860

Association of the APC gene product with beta-catenin

A genetic model for colorectal tumorigenesis

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

Association of the APC tumor suppressor protein with catenins

APC mutations occur early during colorectal tumorigenesis

Identification of FAP locus genes from chromosome 5q21

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA

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