Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes - sprookjes - yvandenbroek - TriplyDB

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

http://www.wikidata.org/entity/Q24564844

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Recent advances in understanding leptin signaling and leptin resistance Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans Novel phenotypes of prediabetes?Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway Leptin signaling and leptin resistance Brain regulation of energy balance and body weight.Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells Weight-sparing effect of insulin detemir: a consequence of central nervous system-mediated reduced energy intake?Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells The role of insulin receptor substrate 2 in hypothalamic and beta cell function.CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.β-cell mass in people with type 2 diabetes.Current views on type 2 diabetes.Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth Insulin action in brain regulates systemic metabolism and brain function.Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Insulin promotes glycogen storage and cell proliferation in primary human astrocytes.Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth Evaluation of A2BP1 as an obesity gene.Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Transcriptome analysis of food habit transition from carnivory to herbivory in a typical vertebrate herbivore, grass carp Ctenopharyngodon idella.Immunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and brainstem.Pancreatic signals controlling food intake; insulin, glucagon and amylin Hypothalamic gene expression underlying pre-hibernation satiety Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age.Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

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Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

http://www.wikidata.org/entity/Q24564844

description

2004 nî lūn-bûn

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2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Dysregulation of insulin recep ...... in causes obesity and diabetes

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Dysregulation of insulin recep ...... in causes obesity and diabetes

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Dysregulation of insulin recep ...... in causes obesity and diabetes

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Dysregulation of insulin recep ...... in causes obesity and diabetes

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Journal of Clinical Investigation

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Dysregulation of insulin recep ...... in causes obesity and diabetes

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Akiko Taguchi

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Fan Li

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Jake A Kushner

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Morris F White

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Sunmin Park

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Xueying Lin

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Yedan Li

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P2860

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Disruption of IRS-2 causes type 2 diabetes in mice

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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908-16

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scholarly article

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1301116

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10.1172/JCI22217

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P433

7

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114

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2004-10-01T00:00:00Z

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15467829

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518668

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