Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
about
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathAn atomic structure of the human 26S proteasomeAtomicChargeCalculator: interactive web-based calculation of atomic charges in large biomolecular complexes and drug-like moleculesStructural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimerSolution structure of yeast Rpn9: insights into proteasome lid assemblyUnfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study.Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexesStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsInterrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts.Base-CP proteasome can serve as a platform for stepwise lid formationRice stripe tenuivirus nonstructural protein 3 hijacks the 26S proteasome of the small brown planthopper via direct interaction with regulatory particle non-ATPase subunit 3.Gates, Channels, and Switches: Elements of the Proteasome MachineStructural characterization of the interaction of Ubp6 with the 26S proteasome.Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeUbp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.Refining the nuclear auxin response pathway through structural biologyDistinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome AssemblyAtomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradationStructure of an endogenous yeast 26S proteasome reveals two major conformational statesAdvances in the molecular dynamics flexible fitting method for cryo-EM modeling.An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology.Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Structure of the human 26S proteasome at a resolution of 3.9 Å.Structural basis for dynamic regulation of the human 26S proteasome.Gyre and gimble in the proteasome.Structural insights into the functional cycle of the ATPase module of the 26S proteasome.Reversible phosphorylation of the 26S proteasome.Emerging mechanistic insights into AAA complexes regulating proteasomal degradation.Structural disorder and its role in proteasomal degradation.Tuning the proteasome to brighten the end of the journey.Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae.High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.Structural basis for the disaggregase activity and regulation of Hsp104.Proteasome Structure and Assembly.AAA-ATPases in Protein Degradation.
P2860
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P2860
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Deep classification of a large ...... andscape of the 26S proteasome
@ast
Deep classification of a large ...... andscape of the 26S proteasome
@en
Deep classification of a large ...... andscape of the 26S proteasome
@nl
type
label
Deep classification of a large ...... andscape of the 26S proteasome
@ast
Deep classification of a large ...... andscape of the 26S proteasome
@en
Deep classification of a large ...... andscape of the 26S proteasome
@nl
prefLabel
Deep classification of a large ...... andscape of the 26S proteasome
@ast
Deep classification of a large ...... andscape of the 26S proteasome
@en
Deep classification of a large ...... andscape of the 26S proteasome
@nl
P2093
P2860
P3181
P356
P1476
Deep classification of a large ...... andscape of the 26S proteasome
@en
P2093
Andreas Schweitzer
Florian Beck
Friedrich Förster
Günter Pfeifer
Pia Unverdorben
Wolfgang Baumeister
P2860
P304
P3181
P356
10.1073/PNAS.1403409111
P407
P577
2014-03-24T00:00:00Z