The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury - sprookjes - yvandenbroek - TriplyDB

The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury

The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury

http://www.wikidata.org/entity/Q24601910

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic Daily supplementation with GrandFusion® improves memory and learning in aged rats Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.Degradomics in Neurotrauma: Profiling Traumatic Brain Injury.Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides.Cystatin C has a dual role in post-traumatic brain injury recovery.Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment.Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development.Dysfunction of Membrane Trafficking Leads to Ischemia-Reperfusion Injury After Transient Cerebral Ischemia.Dietary supplementation of GrandFusion(®) mitigates cerebral ischemia-induced neuronal damage and attenuates inflammation.The Neuroprotection of Lysosomotropic Agents in Experimental Subarachnoid Hemorrhage Probably Involving the Apoptosis Pathway Triggering by Cathepsins via Chelating Intralysosomal Iron.Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy

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The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury

http://www.wikidata.org/entity/Q24601910

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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The cysteine protease cathepsi ...... ics for traumatic brain injury

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Journal of Neurotrauma

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The cysteine protease cathepsi ...... ics for traumatic brain injury

@en

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Gregory R Hook

http://www.w3.org/2001/XMLSchema#string

Jin Yu

http://www.w3.org/2001/XMLSchema#string

Mark S Kindy

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Michael D Pierschbacher

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Nancy Sipes

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Vivian Hook

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P2860

Lysosomal cysteine proteases: facts and opportunities.

Clinical trials in head injury

Traumatic brain injury: can the consequences be stopped?

Neurobiological consequences of traumatic brain injury

Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)

The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity

Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence.

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway

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515-29

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scholarly article

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10.1089/NEU.2013.2944

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5

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31

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2014-03-01T00:00:00Z

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257299836

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24083575

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traumatic brain injury

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3934599

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