Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides
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Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulinHuman glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active siteProcessing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme InactivationKinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthusStructural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor bindingIdentification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelatorsAssociation of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult womenContulakin-G, an O-glycosylated invertebrate neurotensinSoluble variants of human recombinant glutaminyl cyclaseLinked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivoRole of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell deathNatural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors.Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug developmentGlutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.Substrate specificity of glutaminyl cyclases from plants and animals.Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons.Primary structure of the precursor for the sea anemone neuropeptide Antho-RFamide (less than Glu-Gly-Arg-Phe-NH2).Primary structure and functional expression of a glutaminyl cyclase.Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanismAlzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.Targeting drugs to the brain by redox chemical delivery systems.Novel peptides from adrenomedullary chromaffin vesiclesProline residues in the maturation and degradation of peptide hormones and neuropeptides.PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM.Targeted single-cell microchemical analysis: MS-based peptidomics of individual paraformaldehyde-fixed and immunolabeled neuronsGenetic alterations of the BRI2 gene: familial British and Danish dementias.Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase.Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanismsIsoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.Controversies in TRH biosynthesis and strategies towards the identification of a TRH precursor.Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures.Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer diseaseThe isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens.Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct.
P2860
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P2860
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides
description
1987 nî lūn-bûn
@nan
1987 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@ast
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@en
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@nl
type
label
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@ast
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@en
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@nl
prefLabel
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@ast
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@en
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@nl
P2860
P3181
P356
P1476
Identification of a mammalian ...... nyl into pyroglutamyl peptides
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.84.11.3628
P407
P577
1987-06-01T00:00:00Z