TAp63 prevents premature aging by promoting adult stem cell maintenance - sprookjes - yvandenbroek - TriplyDB

TAp63 prevents premature aging by promoting adult stem cell maintenance

TAp63 prevents premature aging by promoting adult stem cell maintenance

http://www.wikidata.org/entity/Q24618256

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Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging Changing Paradigms in Cranio-Facial Regeneration: Current and New Strategies for the Activation of Endogenous Stem Cells DNA repair and aging: the impact of the p53 family Molecular mechanism of extrinsic factors affecting anti-aging of stem cells p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63 A New C-Xyloside induces modifications of GAG expression, structure and functional properties ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation Senescence (ageing) @ 2011 Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63 Role of p63 and the Notch pathway in cochlea development and sensorineural deafness TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Regulation of p63 protein stability via ubiquitin-proteasome pathway.TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.Hepatic p63 regulates steatosis via IKKβ/ER stress OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.Impact papers on aging in 2009.TAp63 is a transcriptional target of NF-kappaB.p53/p63/p73 in the epidermis in health and disease The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation p63 in skin development and ectodermal dysplasias.TAp63 induces senescence and suppresses tumorigenesis in vivo.p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.p53 Isoforms: An Intracellular Microprocessor?p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.p53: the barrier to cancer stem cell formation.Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration.TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells.IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium While p73 is essential, p63 is completely dispensable for the development of the central nervous system p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.p53 in stem cells

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P2860

TAp63 prevents premature aging by promoting adult stem cell maintenance

http://www.wikidata.org/entity/Q24618256

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

@zh-tw

2009年论文

@wuu

name

TAp63 prevents premature aging by promoting adult stem cell maintenance

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TAp63 prevents premature aging by promoting adult stem cell maintenance

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TAp63 prevents premature aging by promoting adult stem cell maintenance

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type

label

TAp63 prevents premature aging by promoting adult stem cell maintenance

@ast

TAp63 prevents premature aging by promoting adult stem cell maintenance

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TAp63 prevents premature aging by promoting adult stem cell maintenance

@nl

prefLabel

TAp63 prevents premature aging by promoting adult stem cell maintenance

@ast

TAp63 prevents premature aging by promoting adult stem cell maintenance

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TAp63 prevents premature aging by promoting adult stem cell maintenance

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J.STEM.2009.04.003

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TAp63 prevents premature aging by promoting adult stem cell maintenance

@en

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Carol Prives

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Elsa R Flores

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Freda D Miller

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Jeffrey A Biernaskie

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Larysa H Pevny

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Maryline Paris

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Min Soon Cho

http://www.w3.org/2001/XMLSchema#string

Satrajit Sinha

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Xiaohua Su

http://www.w3.org/2001/XMLSchema#string

Young Jin Gi

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P2860

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

Aging and genome maintenance: lessons from the mouse?

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

p63 is the molecular switch for initiation of an epithelial stratification program

p63 protects the female germ line during meiotic arrest

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

p63 is a p53 homologue required for limb and epidermal morphogenesis

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

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64-75

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scholarly article

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3751552

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10.1016/J.STEM.2009.04.003

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1

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5

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Kenneth Y. Tsai

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2009-07-01T00:00:00Z

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26334134

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19570515

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