Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA - sprookjes - yvandenbroek - TriplyDB

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

http://www.wikidata.org/entity/Q24620671

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Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes The role of animal models for research on severe malaria Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum Rosetting Modeling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes-common principles and distinctive features Malaria Parasites: The Great Escape An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes Var2CSA minimal CSA binding region is located within the N-terminal region Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells.Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions.Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death.Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains Designing a VAR2CSA-based vaccine to prevent placental malaria.Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced.A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins.The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site How specific is Plasmodium falciparum adherence to chondroitin 4-sulfate?High-throughput screening platform identifies small molecules that prevent sequestration of Plasmodium falciparum-infected erythrocytes.Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental malaria.Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo.Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women.Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions Influence of Intermittent Preventive Treatment on Antibodies to VAR2CSA in Pregnant Cameroonian Women Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.Pregnancy malaria: cryptic disease, apparent solution.

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P2860

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

http://www.wikidata.org/entity/Q24620671

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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prefLabel

Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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Full-length extracellular regi ...... , high-affinity binding to CSA

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PNAS.1000951107

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Proceedings of the National Academy of Sciences of the United States of America

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Full-length extracellular regi ...... , high-affinity binding to CSA

@en

P2093

Alexandre Juillerat

http://www.w3.org/2001/XMLSchema#string

Benoît Gamain

http://www.w3.org/2001/XMLSchema#string

Bruno Baron

http://www.w3.org/2001/XMLSchema#string

Graham A Bentley

http://www.w3.org/2001/XMLSchema#string

Grazyna Faure

http://www.w3.org/2001/XMLSchema#string

Hassan Belrhali

http://www.w3.org/2001/XMLSchema#string

Saurabh Kumar Singh

http://www.w3.org/2001/XMLSchema#string

Stéphane Gangnard

http://www.w3.org/2001/XMLSchema#string

Stéphanie Ramboarina

http://www.w3.org/2001/XMLSchema#string

Sébastien Dechavanne

http://www.w3.org/2001/XMLSchema#string

P2860

Global rigid body modeling of macromolecular complexes against small-angle scattering data

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria

Human malaria parasites in continuous culture

CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.

Molecular basis for the dichotomy in Plasmodium falciparum adhesion to CD36 and chondroitin sulfate A

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4884-9

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scholarly article

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1270391

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P356

10.1073/PNAS.1000951107

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P433

11

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107

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P50

Patrick England

Bertrand Raynal

Anita Lewit-Bentley

Anand Srivastava

P577

2010-03-16T00:00:00Z

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41656860

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P698

20194779

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erythrocyte membrane protein 1, PfEMP1

P932

2841952

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