DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88 - sprookjes - yvandenbroek - TriplyDB

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

http://www.wikidata.org/entity/Q24621930

about

DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation Restricting retrotransposons: a review Roles for retrotransposon insertions in human disease Production of small RNAs by mammalian Dicer Update on Clinical Trials in Dry Age-related Macular Degeneration Inflammation and its role in age-related macular degeneration Parainflammation, chronic inflammation, and age-related macular degeneration Age-Related Macular Degeneration: Advances in Management and Diagnosis NLRP3 Inflammasome and Pathobiology in AMD Dementia of the eye: the role of amyloid beta in retinal degeneration Photoreceptor cell death and rescue in retinal detachment and degenerations "Seq-ing" insights into the epigenetics of neuronal gene regulation Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer NLRP3 inflammasome: activation and regulation in age-related macular degeneration Mechanisms of age-related macular degeneration The NLRP3 inflammasome and stroke Protection of retina by αB crystallin in sodium iodate induced retinal degeneration A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein RPE necroptosis in response to oxidative stress and in AMD Emerging Roles for the Immune System in Traumatic Brain Injury What Drives Positive Selection in the Drosophila piRNA Machinery? The Genomic Autoimmunity Hypothesis IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies Alu mobile elements: from junk DNA to genomic gems Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells.Molecular mechanisms of Dicer: endonuclease and enzymatic activity.Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.The inhibition of NOTCH2 reduces UVB-induced damage in retinal pigment epithelium cells.DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.A glimpse at the aging eye.Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms.Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium.Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration Dynamic Alu methylation during normal development, aging, and tumorigenesis.Studying age-related macular degeneration using animal models.miRNAs at the interface of cellular stress and disease

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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

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J.CELL.2012.03.036

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Balamurali K Ambati

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Benjamin J Fowler

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Bradley D Gelfand

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David R Hinton

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Dong-ki Lee

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Gabriel Núñez

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Gautam Chaudhuri

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Hiroki Kaneko

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Jae Wook Yoo

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James A Goodrich

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P2860

Initial sequencing and analysis of the human genome

The inflammasomes

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

Active caspase-1 is a regulator of unconventional protein secretion

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

IRAK: a kinase associated with the interleukin-1 receptor

CCR3 is a target for age-related macular degeneration diagnosis and therapy

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

How mitochondria produce reactive oxygen species

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