Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53 - sprookjes - yvandenbroek - TriplyDB

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

http://www.wikidata.org/entity/Q24628577

about

Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations Chemical Variations on the p53 Reactivation Theme Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy Targeting Oncogenic Mutant p53 for Cancer Therapy Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization Exploring the role of receptor flexibility in structure-based drug discovery Small molecule compounds targeting the p53 pathway: are we finally making progress?Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue Disulfide isomerase-like protein AtPDIL1-2 is a good candidate for trichlorophenol phytodetoxification Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Parameter choice matters: validating probe parameters for use in mixed-solvent simulations.Molecular dynamics simulations: from structure function relationships to drug discovery.Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Targeting tumor suppressor networks for cancer therapeutics.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.Discovery of Novel Isatin-Based p53 Inducers Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology.Glutamine Synthetase Drugability beyond Its Active Site: Exploring Oligomerization Interfaces and Pockets.Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface.Genetic and functional analysis of a Li Fraumeni syndrome family in China.Molecular simulations of aromatase reveal new insights into the mechanism of ligand binding.RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response.Pharmacological reactivation of p53 as a strategy to treat cancer.TP53: an oncogene in disguise.Combining experimental and simulation data of molecular processes via augmented Markov models.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.A Kepler Workflow Tool for Reproducible AMBER GPU Molecular Dynamics.Structural Evolution and Dynamics of the p53 Proteins.Full-length p53 tetramer bound to DNA and its quaternary dynamics.Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors.Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

P2860

Q26747130-576A94F7-CBEE-4D63-8DAF-EA150D1DBAA6 Q26749008-543A33D8-B032-4CEA-A323-66B56AAB5E68 Q26766341-62E02FD3-AC32-4D10-BE87-9A722E568258 Q26770856-EFD31FEC-4CE7-4520-B113-5D2BE7039B1D Q26996528-C151BA82-EDE1-4B1E-A897-257CDE88E121 Q27001129-8E293FE7-9982-4C79-A16A-02F150590E0F Q27027835-3A8D3180-4281-42F6-BA14-F6E896D7180B Q27680171-2FB0F309-2328-47DE-86D0-902E9C75E9D6 Q28817953-F71247D5-A37B-439F-A4EC-510109861FC4 Q30358225-FE0A69B7-8727-4144-9798-2D4F7E2D17E0 Q30365087-DB2F165F-7438-4C37-BD65-2A15591BDD64 Q30369875-F0A7433B-E79D-4DE7-A1B1-841A7E228AB8 Q30391745-45EACD3A-8B5A-4983-AA5E-0026FAA562C5 Q30392142-1CECB448-1E37-47A8-B6BF-F19E44915CCD Q30394046-E1CB5644-180A-4CC1-874F-8474E4EAA7A0 Q33657519-C63A1A86-1AED-4889-9C0D-CB4C997B6E24 Q33909288-A5DDF70C-897D-4A28-B8BE-95316A6093E3 Q33915380-CD791E15-2D11-4461-A796-A66F271C80A9 Q35063635-A14E4BC1-A275-474D-A9F2-E4D4DF80B4E3 Q35750496-8AD50713-100A-4A3B-9973-346AF4788348 Q35759870-5A284164-605D-4A1C-9DA3-680C4A44B2AF Q35886682-CA5E461F-32D6-4BB1-8A57-D5B37A3BDA82 Q35926542-2F9C1242-F7E6-4B74-AD48-4797767D15BE Q36100472-7932A426-A124-4A1B-A322-72F2AE1A9CB3 Q36198159-C5E3F8F3-73FF-498C-99B1-3A09A03949AA Q36392939-44EBB0E9-37B3-4B91-9804-C81F51D00485 Q36512100-0099AB1A-4BB3-43BC-98A8-6D91E873C9C6 Q37207524-DDC0604E-F02A-4F45-8399-2785284AC37B Q38147113-9FB57A29-D010-45EF-BFD9-12B4E1BCD7C3 Q38286198-BB4D1CAE-2174-4397-89A1-DFE4E629FD3F Q38507513-DB5A9433-909D-4FE7-B28F-2AE373F1C52E Q38674854-A0E57BDF-CBD0-4DBA-95A2-DEF0C63155EC Q38675922-051BD03C-FF0A-4CDB-859F-E379C2CEE6BA Q38715489-68AFED33-33FE-4FE6-B296-8FDEBCE3AE67 Q38811603-348675D3-5E3E-4D7F-9ACD-FD270EFFFD65 Q38820037-E4642C77-3783-4E65-BF54-BCA7345052F0 Q38934098-3249312F-97BB-4177-9B96-5B7BE841B20E Q39152860-1CEFA799-9E49-4C75-9BCF-68E354A07DBF Q39673538-10ECA9FA-0270-4498-A864-FE5BBBD19FF1 Q40242926-BA3AF885-F57B-4CA1-8F6B-60B65B5CDDC3

P2860

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

http://www.wikidata.org/entity/Q24628577

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Computational identification o ...... for reactivation of mutant p53

@ast

Computational identification o ...... for reactivation of mutant p53

@en

Computational identification o ...... for reactivation of mutant p53

@nl

type

label

Computational identification o ...... for reactivation of mutant p53

@ast

Computational identification o ...... for reactivation of mutant p53

@en

Computational identification o ...... for reactivation of mutant p53

@nl

prefLabel

Computational identification o ...... for reactivation of mutant p53

@ast

Computational identification o ...... for reactivation of mutant p53

@en

Computational identification o ...... for reactivation of mutant p53

@nl

P1433

Q24628577-1D1BADDB-292D-4148-B1C8-46E7DAB57987

P1476

Q24628577-79040ECD-0B1E-46B8-B97B-E0CA9911341E

P2093

Q24628577-150AE7E9-F930-4FBF-86EA-CF334E140817

Q24628577-19D5E3E5-8A55-4E33-A061-D396F61C2166

Q24628577-266FED6C-71AD-4089-92AA-7B7D77834297

Q24628577-2D7E4532-6F14-4B9E-B9BC-EDFDF8E8DB05

Q24628577-366D0052-C79F-47D5-BFB7-F7D5051035C5

Q24628577-38754FD0-6493-4CE4-BBD3-A8927FAAE732

Q24628577-412C4761-A633-4D95-B274-20B53EDA12D4

Q24628577-5C6158B6-0912-4B1D-9E8D-F54B699E8E89

Q24628577-9169A94B-BB83-4F23-BF15-E52CFE771E53

Q24628577-9E06BD09-0BA3-4D6B-BE09-0D3B4C8B1E06

P2860

Q24628577-054886C6-5734-4B45-9AE4-F28EEC4E1B63

Q24628577-0679482E-4A61-43A4-A284-AEC432CD02A2

Q24628577-0A1C16EE-759B-404D-B695-974A73094417

Q24628577-10508090-4112-47CF-B042-CCBCC7319CBD

Q24628577-1093A17B-F908-4D3D-A485-4604C190F8F9

Q24628577-11BBD423-2109-474E-A3FE-05CA468E58F9

Q24628577-126E6121-C499-4371-BCE8-15A8C3E6B2C7

Q24628577-19A43344-A534-4A9F-AECC-53576B12F1AA

Q24628577-1B3FFAAD-9ECA-455D-91A4-7D1A92897A77

Q24628577-1BFEC731-E398-4472-A784-7EF56B870C3A

P2888

Q24628577-46EA7BFB-2DA8-443F-8031-B9BD1890E1C3

P304

Q24628577-CB1A60CE-A06A-44D1-BF18-DEE1CE8C406C

P31

Q24628577-CE8E53AE-A9B5-4F71-BB10-87545D53414A

P3181

Q24628577-2D23884E-9CDC-4A3F-B294-7C532E25F2A7

P356

Q24628577-7D49F5A0-36D9-46AC-802F-8168702F64A9

P407

Q24628577-377E2486-EBC0-4FFE-A578-5C0E45EE3B16

P478

Q24628577-69B03938-4012-44D6-BC5E-E43CEE7F722B

P50

Q24628577-BD2BE3A6-DF55-4F3D-BAF8-7C7677780A39

P577

Q24628577-94954160-8125-4D9D-B5CE-847C2A75F399

P5875

Q24628577-5BFFC87A-2383-4249-9296-FB13823A93AB

P6179

Q24628577-11228DB0-4909-4E78-9925-42E0300971AF

P698

Q24628577-578C463A-A5D0-4212-B61B-B9BBF75AF6FE

P932

Q24628577-A101C429-EE86-4FF6-98E8-82F18C62E525

P3181

P356

P1433

Nature Communications

P1476

Computational identification o ...... for reactivation of mutant p53

@en

P2093

A Richard Chamberlin

http://www.w3.org/2001/XMLSchema#string

Benjamin P Chung

http://www.w3.org/2001/XMLSchema#string

Brad D Wallentine

http://www.w3.org/2001/XMLSchema#string

Chiung-Kuang Chen

http://www.w3.org/2001/XMLSchema#string

Christopher D Wassman

http://www.w3.org/2001/XMLSchema#string

Da-Wei Lin

http://www.w3.org/2001/XMLSchema#string

Faezeh Salehi

http://www.w3.org/2001/XMLSchema#string

G Wesley Hatfield

http://www.w3.org/2001/XMLSchema#string

Hartmut Luecke

http://www.w3.org/2001/XMLSchema#string

Linda V Hall

http://www.w3.org/2001/XMLSchema#string

P2860

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

Thermodynamic stability of wild-type and mutant p53 core domain

MolProbity: all-atom structure validation for macromolecular crystallography

The PMDB Protein Model Database

Comparison of simple potential functions for simulating liquid water

Structure of the human p53 core domain in the absence of DNA

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

Crystal structure of a p53 core tetramer bound to DNA

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

P2888

P304

1407

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

877400

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NCOMMS2361

http://www.w3.org/2001/XMLSchema#string

P407

P478

4

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

235382351

http://www.w3.org/2001/XMLSchema#string

P6179

1009779547

http://www.w3.org/2001/XMLSchema#string

P698

23360998

http://www.w3.org/2001/XMLSchema#string

P932

3562459

http://www.w3.org/2001/XMLSchema#string