Mitochondrial dysfunction in ataxia-telangiectasia - sprookjes - yvandenbroek - TriplyDB

Mitochondrial dysfunction in ataxia-telangiectasia

Mitochondrial dysfunction in ataxia-telangiectasia

http://www.wikidata.org/entity/Q24630465

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BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies Chromatin perturbations during the DNA damage response in higher eukaryotes Autophagy in cancer Autophagy in malignant transformation and cancer progression Autophagy modulation as a potential therapeutic target for diverse diseases Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions ATM functions at the peroxisome to induce pexophagy in response to ROS.Systemic DNA damage responses in aging and diseases Ataxia telangiectasia: a review DNA Damage Response and Autophagy: A Meaningful Partnership Nuclear DNA damage signalling to mitochondria in ageing A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.Is Huntingtin Dispensable in the Adult Brain?Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.ATM and the epigenetics of the neuronal genome.ATM signalling and cancer.The ATM protein: the importance of being active.Reactive oxygen species in normal and tumor stem cells.Mitochondria, energetics, epigenetics, and cellular responses to stress.SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs.Molecular pathways: autophagy in cancer--a matter of timing and context.Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.Tug of war between survival and death: exploring ATM function in cancer.Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors.Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.Translational initiation regulated by ATM in dendritic cells development Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury.

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Mitochondrial dysfunction in ataxia-telangiectasia

http://www.wikidata.org/entity/Q24630465

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2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Mitochondrial dysfunction in ataxia-telangiectasia

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Frank C Dorsey

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Jacqueline Tait-Mulder

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John L Cleveland

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Kirsteen H Maclean

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Meredith Steeves

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Michael B Kastan

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Sandra Milasta

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Yasmine A Valentin-Vega

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P2860

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

DJ-1 has a role in antioxidative stress to prevent cell death

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Multiple roles of ATM in monitoring and maintaining DNA integrity

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

ATM binds to beta-adaptin in cytoplasmic vesicles

Mechanisms of mitophagy

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

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1490-500

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6

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Douglas R. Green

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