Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
about
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesisPHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthScribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of AktPHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in micePurinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatasesThe de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signalingDiverse mechanisms of AKT pathway activation in human malignancyTurning off AKT: PHLPP as a drug targetPTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastomaWD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicitySuppression of survival signalling pathways by the phosphatase PHLPPNF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1The pursuit of oncotargets through understanding defective cell regulationCutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cellsRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesCSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site.Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis.Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancerCurcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling.Integrative epigenomic and genomic analysis of malignant pheochromocytoma.Akt: a double-edged sword in cell proliferation and genome stability.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancerAberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinomaMiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1.Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma.MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulationPleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinomaThe phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer.PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
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P2860
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@ast
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@en
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@nl
type
label
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@ast
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@en
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@nl
prefLabel
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@ast
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@en
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@nl
P2093
P2860
P3181
P356
P1433
P1476
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/ONC.2008.450
P407
P577
2008-12-15T00:00:00Z
P5875
P6179
1010131513