New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress - sprookjes - yvandenbroek - TriplyDB

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

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The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation Effect of redox modulating NRF2 activators on chronic kidney disease Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease Changes in Renal Function and Oxidative Status Associated with the Hypotensive Effects of Oleanolic Acid and Related Synthetic Derivatives in Experimental Animals Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum.A synthetic chalcone as a potent inducer of glutathione biosynthesis The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR A novel synthetic oleanane triterpenoid suppresses adhesion, migration, and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis.Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Emerging drugs for chronic kidney disease.Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits.A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation.CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury.Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model.Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation.Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice.Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention Triterpenoids and flavonoids from Cecropia schreberiana Miq. (Urticaceae)The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II-induced contraction of glomerular mesangial cells

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P2860

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

http://www.wikidata.org/entity/Q24632281

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

New synthetic triterpenoids: p ...... lammatory and oxidative stress

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New synthetic triterpenoids: p ...... lammatory and oxidative stress

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Journal of Natural Products

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New synthetic triterpenoids: p ...... lammatory and oxidative stress

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Gordon W Gribble

http://www.w3.org/2001/XMLSchema#string

Justin M Lopchuk

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Karen T Liby

http://www.w3.org/2001/XMLSchema#string

Liangfeng Fu

http://www.w3.org/2001/XMLSchema#string

Mark M Yore

http://www.w3.org/2001/XMLSchema#string

Michael B Sporn

http://www.w3.org/2001/XMLSchema#string

P2860

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Oxidative stress as a major culprit in kidney disease in diabetes

Pharmacology of oleanolic acid and ursolic acid

Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.

Points of control in inflammation

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.

Site-specific binding of quinones to proteins through thiol addition and addition-elimination reactions.

Reversible Michael addition of thiols as a new tool for dynamic combinatorial chemistry.

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537-45

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4813487

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10.1021/NP100826Q

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3

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74

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49825173

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21309592

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Aagianik kimischri

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3064114

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