On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
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MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPsCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsStaurosporine-Derived Inhibitors Broaden the Scope of Analog-Sensitive Kinase TechnologyGlobal analysis of small molecule binding to related protein targetsInterpretation of the consequences of mutations in protein kinases: combined use of bioinformatics and text mining.Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Probing the probes: fitness factors for small molecule tools.Generation and characterization of ATP analog-specific protein kinase Cδ.Predictive in silico off-target profiling in drug discovery.Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials.Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.Targeting PAK1.Exploiting Octahedral Stereocenters: From Enzyme Inhibition to Asymmetric Photoredox Catalysis.Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications.CREDO: a structural interactomics database for drug discovery.Considerations of Protein Subpockets in Fragment-Based Drug Design.The human kinome and kinase inhibition.Copper-induced activation of TRP channels promotes extracellular calcium entry, activation of CaMs and CDPKs, copper entry and membrane depolarization in Ulva compressa.Synthesis of piperazine-based thiazolidinones as VEGFR2 tyrosine kinase inhibitors inducing apoptosis.Design, Synthesis, and Evaluation of the Kinase Inhibition Potential of Pyridylpyrimidinylaminophenyl Derivatives.A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure-activity relationship study and analysis of interactions.Toward mobile 3D visualization for structural biologists.Copper-induced activation of TRPs and VDCCs triggers a calcium signature response regulating gene expression in Ectocarpus siliculosus.Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us
P2860
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P2860
On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
On the origins of enzyme inhib ...... inase binding to staurosporine
@ast
On the origins of enzyme inhib ...... inase binding to staurosporine
@en
On the origins of enzyme inhib ...... inase binding to staurosporine
@nl
type
label
On the origins of enzyme inhib ...... inase binding to staurosporine
@ast
On the origins of enzyme inhib ...... inase binding to staurosporine
@en
On the origins of enzyme inhib ...... inase binding to staurosporine
@nl
prefLabel
On the origins of enzyme inhib ...... inase binding to staurosporine
@ast
On the origins of enzyme inhib ...... inase binding to staurosporine
@en
On the origins of enzyme inhib ...... inase binding to staurosporine
@nl
P2860
P50
P3181
P1476
On the origins of enzyme inhib ...... inase binding to staurosporine
@en
P2093
William R Pitt
P2860
P3181
P356
10.1111/J.1747-0285.2009.00832.X
P407
P577
2009-07-01T00:00:00Z