The RNA polymerase "switch region" is a target for inhibitors
about
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotidesStructures of RNA polymerase-antibiotic complexesTagetitoxin inhibits RNA polymerase through trapping of the trigger loopResponse to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcriptionOpening and closing of the bacterial RNA polymerase clampNew target for inhibition of bacterial RNA polymerase: 'switch region'Elucidating the inhibition mechanism of HIV-1 non-nucleoside reverse transcriptase inhibitors through multicopy molecular dynamics simulationsAntibiotics from predatory bacteriaThree-dimensional EM structure of an intact activator-dependent transcription initiation complexCrystal structure of bacterial RNA polymerase bound with a transcription inhibitor proteinX-ray Crystal Structure of Escherichia coli RNA Polymerase 70 HoloenzymeHIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanismInteraction of the Mediator Head Module with RNA Polymerase IIStructural basis for promoter specificity switching of RNA polymerase by a phage factorTranscription inhibition by the depsipeptide antibiotic salinamide ABacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug ActionAntibacterial Nucleoside-Analog Inhibitor of Bacterial RNA PolymeraseSolving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis.Molecular evolution of multisubunit RNA polymerases: structural analysisA prehydrolysis state of an AAA+ ATPase supports transcription activation of an enhancer-dependent RNA polymeraseMultiple roles of the RNA polymerase {beta}' SW2 region in transcription initiation, promoter escape, and RNA elongation.Structural basis of transcription activationCoupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex.Structural biology of bacterial RNA polymerase.A critical role of downstream RNA polymerase-promoter interactions in the formation of initiation complex.The β subunit gate loop is required for RNA polymerase modification by RfaH and NusG.A detailed study of antibacterial 3-acyltetramic acids and 3-acylpiperidine-2,4-diones.Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.Bacterial Transcription as a Target for Antibacterial Drug Development.TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycleAllosteric control of Escherichia coli rRNA promoter complexes by DksA.Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP.CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.Bacterial transcription terminators: the RNA 3'-end chronicles.How to cope with the quest for new antibiotics.Screening strategies for discovery of antibacterial natural products.Archaeology of RNA polymerase: factor swapping during the transcription cycle.Total synthesis of antibiotics: recent achievements, limitations, and perspectives.
P2860
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P2860
The RNA polymerase "switch region" is a target for inhibitors
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The RNA polymerase "switch region" is a target for inhibitors
@ast
The RNA polymerase "switch region" is a target for inhibitors
@en
The RNA polymerase "switch region" is a target for inhibitors
@nl
type
label
The RNA polymerase "switch region" is a target for inhibitors
@ast
The RNA polymerase "switch region" is a target for inhibitors
@en
The RNA polymerase "switch region" is a target for inhibitors
@nl
altLabel
The RNA Polymerase “Switch Region” Is a Target for Inhibitors
@en
prefLabel
The RNA polymerase "switch region" is a target for inhibitors
@ast
The RNA polymerase "switch region" is a target for inhibitors
@en
The RNA polymerase "switch region" is a target for inhibitors
@nl
P2093
P2860
P50
P3181
P1433
P1476
The RNA polymerase "switch region" is a target for inhibitors
@en
P2093
Brian Hudson
David Koppstein
Eddy Arnold
Herbert Irschik
Jayanta Mukhopadhyay
Minyoung Jang
Rolf Jansen
Sajida Ismail
Steven Tuske
P2860
P304
P3181
P356
10.1016/J.CELL.2008.09.033
P407
P577
2008-10-01T00:00:00Z