Roles of Werner syndrome protein in protection of genome integrity - sprookjes - yvandenbroek - TriplyDB

Roles of Werner syndrome protein in protection of genome integrity

Roles of Werner syndrome protein in protection of genome integrity

http://www.wikidata.org/entity/Q24643050

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The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures The Werner syndrome protein: linking the replication checkpoint response to genome stability Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology Replication-Associated Recombinational Repair: Lessons from Budding Yeast Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation RecQ helicases in DNA double strand break repair and telomere maintenance.Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ DNA replication arrest leads to enhanced homologous recombination and cell death in meristems of rice OsRecQl4 mutants.Oxidative stress and antioxidant response in fibroblasts from Werner and atypical Werner syndromes.The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.Accelerated epigenetic aging in Werner syndrome Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs.Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth Hyper telomere recombination accelerates replicative senescence and may promote premature aging.The aging stress response.Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures Nucleolar stress with and without p53.Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.DNA double-strand break repair in Caenorhabditis elegans Dysregulation of RNA polymerase I transcription during disease.Helicase-inactivating mutations as a basis for dominant negative phenotypes.Metabolism, genomics, and DNA repair in the mouse aging liver.The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice.Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.DNA helicases involved in DNA repair and their roles in cancer DNA helicases associated with genetic instability, cancer, and aging.G4-associated human diseases.Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry.Homologous recombination and its regulation Stem cell aging in adult progeria.

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Roles of Werner syndrome protein in protection of genome integrity

http://www.wikidata.org/entity/Q24643050

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2010 nî lūn-bûn

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年論文

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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Roles of Werner syndrome protein in protection of genome integrity

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J.DNAREP.2009.12.011

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Roles of Werner syndrome protein in protection of genome integrity

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Avik K Ghosh

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Marie L Rossi

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Vilhelm A Bohr

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P2860

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

Mammalian telomeres end in a large duplex loop

Functional and physical interaction between WRN helicase and human replication protein A

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Crystal structure of parallel quadruplexes from human telomeric DNA

Instability and decay of the primary structure of DNA

Ku complex interacts with and stimulates the Werner protein

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

Characterization of the human and mouse WRN 3'-->5' exonuclease

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

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