Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow - sprookjes - yvandenbroek - TriplyDB

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

http://www.wikidata.org/entity/Q24645717

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Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors RASopathies: unraveling mechanisms with animal models The Role of Stroma in Tumor Development Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1 A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor MAPK pathway activation in pilocytic astrocytoma A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1 FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis The difficulty of targeting cancer stem cell niches Principles of cancer therapy: oncogene and non-oncogene addiction Optimizing biologically targeted clinical trials for neurofibromatosis.Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.Tumors as organs: complex tissues that interface with the entire organism Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer.Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells Mast cells and the neurofibroma microenvironment Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.The NF1 gene revisited - from bench to bedside.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.The development of cutaneous neurofibromas.The pathoetiology of neurofibromatosis 1 The role of mast cells in cancers.

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P2860

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

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Dennis Burns

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Feng-Chun Yang

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Gary Hutchins

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Menggang Yu

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Saeed T Vakili

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The Hallmarks of Cancer

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Inflammation and cancer

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

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