Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow
about
Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitorsRASopathies: unraveling mechanisms with animal modelsThe Role of Stroma in Tumor DevelopmentEliminating barriers to personalized medicine: learning from neurofibromatosis type 1A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorMAPK pathway activation in pilocytic astrocytomaA murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formationThe haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasMourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complexPreclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imagingThe 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatmentSocial learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinaseQuantitative assessment of whole-body tumor burden in adult patients with neurofibromatosisThe difficulty of targeting cancer stem cell nichesPrinciples of cancer therapy: oncogene and non-oncogene addictionOptimizing biologically targeted clinical trials for neurofibromatosis.Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromesMolecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsCardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.Tumors as organs: complex tissues that interface with the entire organismEvidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiencyEffect of aerobic exercise on tumor physiology in an animal model of human breast cancer.Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumoursActivity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform NeurofibromasDiscovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cellsMast cells and the neurofibroma microenvironmentUltrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic gliomaBone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.The NF1 gene revisited - from bench to bedside.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibromaSerum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.The development of cutaneous neurofibromas.The pathoetiology of neurofibromatosis 1The role of mast cells in cancers.
P2860
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P2860
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@ast
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@en
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@nl
type
label
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@ast
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@en
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@nl
prefLabel
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@ast
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@en
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@nl
P2093
P2860
P3181
P1433
P1476
Nf1-dependent tumors require a ...... nd c-kit-dependent bone marrow
@en
P2093
D Wade Clapp
David A Ingram
Dennis Burns
Feng-Chun Yang
Gary Hutchins
Kent Robertson
Luis F Parada
Menggang Yu
Saeed T Vakili
P2860
P304
P3181
P356
10.1016/J.CELL.2008.08.041
P407
P577
2008-10-31T00:00:00Z