Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice
about
Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells.A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infectionFunctional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 proteinHerpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic stepAssociation of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzymeP-TEFb goes viralThe EICP22 protein of equine herpesvirus 1 physically interacts with the immediate-early protein and with itself to form dimers and higher-order complexesPosttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localizeHerpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection.ICP0 induces the accumulation of colocalizing conjugated ubiquitin.The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells.Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome.Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors.Role of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress.Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1.Herpes simplex virus reorganizes the cellular DNA repair and protein quality control machinery.Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins.The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.Immunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1.Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is presentHerpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells.Colocalization of the herpes simplex virus 1 UL4 protein with infected cell protein 22 in small, dense nuclear structures formed prior to onset of DNA synthesisICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1.Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functionscdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factorMutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.Construction and properties of a viable herpes simplex virus 1 recombinant lacking coding sequences of the alpha 47 geneHerpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicitySite specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.The herpes simplex virus type 1 UL3 transcript starts within the UL3 open reading frame and encodes a 224-amino-acid proteinHerpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions.Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongationAntiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes.Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.
P2860
Q22003919-EC275A2C-573E-46C2-8810-0EA9E51351E9Q22009164-7579A235-F62C-42B9-A4FE-B477E1857054Q24517275-1073BB25-2E07-4E31-937F-0AF94DE984B4Q24529096-40132321-719E-4E16-A71F-E01DBB4BAA35Q24537648-19308633-6DBA-495C-9A0E-245EE9F088ADQ26741360-952959EA-ABC1-4451-B6ED-A0AA6E484F50Q27933156-F1F87AC6-1220-471A-BC1F-7D34A02485E4Q28345181-BA59DBE1-44A9-4E3E-8304-1E066260610EQ30434945-95FFBCCC-D435-4FDB-92E4-BCFDB328607EQ33603489-610147AB-4E25-4936-9166-98FAC6B1DA72Q33643356-6AC7A6FE-EA6B-4FA1-AFA2-2CDB2042129AQ33669860-863F6304-351E-4164-B5F2-6D272CDEA130Q33721075-E50879E2-1367-4974-AE75-F57A96AF2095Q33744046-34AF1EDD-EADD-444E-A40B-B9AE193C93F2Q33752257-9427CF44-20C3-4E35-8D95-19DDBFCFEE61Q33760836-1448AAC6-5FDC-488D-8C54-3F46F8631779Q33783411-17CB2778-B2C9-4D52-A112-5D1D5D71787AQ33788934-C5A5EC19-E636-4EEA-A3F1-B5264AC76212Q33794645-DAD1A4FA-AF7A-414D-B5AF-85FCDB22C06CQ33795505-2411BD81-A1EC-4B84-87FF-10179DD25460Q33800574-B9524F7F-8B7E-4556-BA22-CB056B4D4128Q33814451-23FCA07A-2E47-4366-A4A5-86BFFE2DBE36Q33815308-6F98B5F3-88B8-4016-A7D9-8FB71C50DC08Q33825495-F68FF5B6-CB8A-4312-8406-30D2943BD65CQ33843248-A7C01E9C-E44F-4451-A305-1AC71A9E689CQ33847970-60BF8BA7-A917-4D3F-AF8D-687F2A2A714AQ33853728-E6C003CE-1B80-4624-A013-DDA99484AEBBQ33929730-7528AAD9-5D9E-4AA5-B1DF-1394D1C2AB3CQ34227708-BF636BB0-2837-4779-84CA-933CB049D326Q34302693-68EE927C-1596-45C7-A088-23B2B45C82F9Q34358090-DCCF66B8-2F59-4017-9B7D-D0A9911FCF7AQ34649460-C4B791B8-02C5-4B15-9611-C5DFF09FB728Q34960919-5C6D7CB2-D42D-45B8-B137-E2109CA1B7B4Q35044114-B4DB22CB-AC32-402E-9C98-3E605A8DADA5Q35101439-80AACAD5-0EB5-4A37-80D5-60E4D41B2C4FQ35220880-F5153F98-3D6B-496C-8CF0-CC8313DDD1E7Q35261303-F81F6A03-A700-4A77-9E29-63060CB5AE5FQ35601772-016CE98F-2509-421C-8E25-741905BAA76DQ35604596-63842359-FF55-45D3-A55E-B35C3519281CQ35611914-8C4D46C6-0CFE-4779-933D-A11DE68FF11B
P2860
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice
description
1985 nî lūn-bûn
@nan
1985 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@ast
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@en
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@nl
type
label
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@ast
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@en
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@nl
prefLabel
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@ast
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@en
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@nl
P2093
P2860
P1433
P1476
Herpes simplex virus 1 mutant ...... tablishment of latency in mice
@en
P2093
B Meignier
I W Halliburton
P2860
P304
P407
P577
1985-08-01T00:00:00Z