Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor
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Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plantsBio-enhancing Effect of Piperine with Metformin on Lowering Blood Glucose Level in Alloxan Induced Diabetic MiceHPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site.Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activityGene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach.Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats.Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activityA polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation.Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP.Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies.Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteersPharmacokinetic interaction of curcumin and glibenclamide in diabetic rats.UGT concentrations in human rectal tissue after multidose, oral curcuminThe effect of piperine on midazolam plasma concentration in healthy volunteers, a research on the CYP3A-involving metabolism.Dietary regulation of P-gp function and expression.Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model.Curcumin molecular targets in obesity and obesity-related cancers.Polypharmacy and food-drug interactions among older persons: a review.Black pepper and health claims: a comprehensive treatise.Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products.Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities.Effect of breastfeeding piperine on the learning of offspring mice: interaction with caffeine and diazepam.Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites.Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice.Protective effects of curcumin against aflatoxicosis: A comprehensive review.Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress.Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids.Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats.Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model.The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers.Selective reduction in the expression of UGTs and SULTs, a novel mechanism by which piperine enhances the bioavailability of curcumin in rat.Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin.
P2860
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P2860
Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@ast
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@en
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@nl
type
label
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@ast
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@en
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@nl
prefLabel
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@ast
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@en
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@nl
P2093
P2860
P356
P1476
Curcuminoids inhibit multiple ...... ely selective CYP3A4 inhibitor
@en
P2093
John R Cashman
Laurie P Volak
Michael H Court
Senait Ghirmai
P2860
P304
P356
10.1124/DMD.108.020552
P407
P577
2008-08-01T00:00:00Z