Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
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Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancerCancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasionProgress of molecular targeted therapies for prostate cancersCancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers.Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetesPI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionMitochondria targeting nano agents in cancer therapeutics (Review)Induction of premature senescence by hsp90 inhibition in small cell lung cancerPhase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancerMetabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.A neuronal network of mitochondrial dynamics regulates metastasis.Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma.Anti-leukemia activity of a Hsp70 inhibitor and its hybrid moleculesMitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cellsCombination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristicsGlobal targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.Insight into nanoparticle cellular uptake and intracellular targetingPreclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancerCombined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.Signaling the mitochondrial unfolded protein response.Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitorsExploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cellsRepercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.Sorafenib exerts anti-glioma activity in vitro and in vivo.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegenerationDisabling mitochondrial reprogramming in cancerConcomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells.Broad targeting of resistance to apoptosis in cancer.Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from MitochondriaMolecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy.Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells.Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis
P2860
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P2860
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@ast
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@en
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@nl
type
label
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@ast
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@en
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@nl
prefLabel
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@ast
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@en
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@nl
P2093
P2860
P50
P3181
P356
P1476
Combinatorial drug design targ ...... trolled by mitochondrial Hsp90
@en
P2093
Bradley Scroggins
Dario C Altieri
Ho Young Song
Janet Plescia
Kristin Beebe
Len Neckers
P2860
P304
P3181
P356
10.1172/JCI37613
P407
P577
2009-02-23T00:00:00Z