Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
about
Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresThe role of Cdc25A in the regulation of cell proliferation and apoptosisNetwork architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptorCiclopirox inhibits cancer cell proliferation by suppression of Cdc25A.Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoMechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.SCF ubiquitin ligases in the maintenance of genome stability.Chemotherapy induced DNA damage response: convergence of drugs and pathwaysIt takes two to tango: Ubiquitin and SUMO in the DNA damage response.CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.Checkpoint control and cancer.CRL Ubiquitin Ligases and DNA Damage Response.Pathways for genome integrity in G2 phase of the cell cycle.Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis.Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategiesChk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration-dependent manner in cancer cells.A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.Chromosome ends teach unexpected lessons on DNA damage signallingCarboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast.
P2860
Q26851196-1647E269-F550-42E7-9872-D5F1E883C3B4Q28387570-37418686-AF4F-4D5F-9FF8-5A1B48799CB8Q28611420-729A7B0B-49F7-4E7E-81C2-410BF61199F1Q33474752-50E5C136-445E-4D80-9A14-6E2F355971C6Q33593849-5EC29A3D-A5AE-4DBD-826E-CCC7A7431F59Q33849693-E0FB6F82-FD1D-4C93-B9F2-42172E3864DAQ33905800-F1F9B977-562B-4814-9954-CD5370EF46D3Q34051616-7FFC8C7A-22B4-4773-A36A-9DD79E8620C2Q34241074-7621594C-AABB-413B-A725-1ABDBE901F64Q34482050-C830A173-AF2A-4BEE-AC85-5D9C99FF1E65Q35754115-0BFCC0D4-B670-4FC5-B9F7-812A3BFD15B1Q36901484-A1DA0587-7905-4704-91C6-72A1FAC3F286Q36917433-58C9996B-979C-4E56-AADD-3204237E7ED5Q37103465-58C95F55-21E1-48BF-8006-1F0F0613A14EQ37190330-6301C052-1BF1-47BA-BD4B-2CB9CA3E2AE9Q37199458-87918842-E99D-4F51-8A8C-A1F29B456681Q37235809-9CAB2D7C-0BCF-4571-82B2-CA3DD965273EQ37525832-63DA0C1B-C384-4238-A8EF-393AFF6ED42BQ37938398-CBC0FCE1-23E3-47C4-974D-B2E83CED1147Q37941374-10AA8400-19D2-45F2-A2AC-AB710EB66B99Q38015388-732D6EA9-F126-4AC6-9922-EE7BEAA0B5BBQ38223676-C42135C7-B7E5-4964-ABE7-D050DB70818EQ38335300-A6ABAFED-3690-4885-B7D1-B9E8193A25B4Q38364071-FA4F922E-5339-4589-93A5-C4C25122C149Q39550369-3081E243-8AED-417C-8ED3-4E4FE1914919Q40001828-36F3EF03-F86F-4E8A-8A3E-00671C706FACQ41362934-ECB117EB-1D01-4F3D-9B99-FB282B2861B0Q41412917-3247277A-5C9F-494F-B177-3396D2B9EB2AQ41820684-3493EB4B-3345-4E69-9322-3DF9E974FE14Q44361179-F4E48497-7109-4DB2-A3C1-12BF3EF81BEB
P2860
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@ast
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@en
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@nl
type
label
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@ast
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@en
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@nl
prefLabel
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@ast
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@en
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@nl
P2093
P2860
P356
P1476
Differential roles for checkpo ...... the Cdc25A protein phosphatase
@en
P2093
Jianping Jin
Xiaolu L Ang
P2860
P304
19322-19328
P356
10.1074/JBC.M802474200
P407
P577
2008-05-13T00:00:00Z