Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
about
A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNADNA replication at the single-molecule levelCharacterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6MCM-BP regulates unloading of the MCM2-7 helicase in late S phaseConserved nucleosome positioning defines replication originsThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationHow do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?The Eukaryotic Replisome Goes Under the MicroscopeStructural Mechanisms of Hexameric Helicase Loading, Assembly, and UnwindingArchaeal MCM Proteins as an Analog for the Eukaryotic Mcm2-7 Helicase to Reveal Essential Features of Structure and FunctionMechanisms for initiating cellular DNA replicationThe Mcm2-7 replicative helicase: a promising chemotherapeutic targetThe minichromosome maintenance replicative helicaseLoading and activation of DNA replicative helicases: the key step of initiation of DNA replicationNew insights into replisome fluidity during chromosome replicationStructure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocationSpatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.MCM ring hexamerization is a prerequisite for DNA-binding.Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.Structure of a DNA Polymerase -Primase Domain That Docks on the SV40 Helicase and Activates the Viral PrimosomeSolution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM MotifMini-chromosome maintenance complexes form a filament to remodel DNA structure and topologyMcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil DomainA conserved MCM single-stranded DNA binding element is essential for replication initiationStructure of the eukaryotic MCM complex at 3.8 ÅThe replication initiation protein Sld2 regulates helicase assembly.The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.How MCM loading and spreading specify eukaryotic DNA replication initiation sitesReplication stress: getting back on trackRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityAn Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication InitiationInsights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.Helicase loading at chromosomal origins of replicationThe structural basis for MCM2-7 helicase activation by GINS and Cdc45.Identification of functional elements and regulatory circuits by Drosophila modENCODEThe Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation.
P2860
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P2860
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@ast
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@en
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@nl
type
label
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@ast
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@en
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@nl
prefLabel
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@ast
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@en
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@nl
P2093
P2860
P3181
P1433
P1476
Concerted loading of Mcm2-7 do ...... A replication origin licensing
@en
P2093
Edward P Morris
Fabienne Beuron
Gökhan Tolun
Jack D Griffith
P2860
P304
P3181
P356
10.1016/J.CELL.2009.10.015
P407
P577
2009-11-05T00:00:00Z