Selective killing of cancer cells by suppression of geminin activity
about
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionGeminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated stateEndoreplicationGenomic instability in cancer.Identification of genes that are essential to restrict genome duplication to once per cell divisionInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell lineGenome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.The dual roles of geminin during trophoblast proliferation and differentiationAn image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cellsExpression of geminin, p16, and Ki67 in cervical intraepithelial neoplasm and normal tissuesGeminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit themThe stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomasLife without geminin.Geminin is required for the maintenance of pluripotency.Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsDistinct activities of the anaphase-promoting complex/cyclosome (APC/C) in mouse embryonic cells.Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western dietThe APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisOverexpression of Cell Cycle Progression Inhibitor Geminin is Associated with Tumor Stem-Like Phenotype of Triple-Negative Breast CancerValidation of Synthetic CRISPR Reagents as a Tool for Arrayed Functional Genomic Screening."The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cellsCip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy.Genome Duplication: The Heartbeat of Developing Organisms.Developmentally programmed endoreduplication in animals.Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.Links between DNA Replication, Stem Cells and Cancer.DNA replication licensing control and rereplication prevention.S-phase-coupled apoptosis in tumor suppression.Quality control in the initiation of eukaryotic DNA replication.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesRegulating DNA replication in eukarya.Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori.Concise Review: Geminin-A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells.Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma: clinical and biological significance.Anti-proliferative effects of physiological concentrations of enterolactone in models of prostate tumourigenesis.
P2860
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P2860
Selective killing of cancer cells by suppression of geminin activity
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Selective killing of cancer cells by suppression of geminin activity
@ast
Selective killing of cancer cells by suppression of geminin activity
@en
Selective killing of cancer cells by suppression of geminin activity
@nl
type
label
Selective killing of cancer cells by suppression of geminin activity
@ast
Selective killing of cancer cells by suppression of geminin activity
@en
Selective killing of cancer cells by suppression of geminin activity
@nl
prefLabel
Selective killing of cancer cells by suppression of geminin activity
@ast
Selective killing of cancer cells by suppression of geminin activity
@en
Selective killing of cancer cells by suppression of geminin activity
@nl
P2860
P3181
P1433
P1476
Selective killing of cancer cells by suppression of geminin activity
@en
P2093
Melvin L Depamphilis
P2860
P304
P3181
P356
10.1158/0008-5472.CAN-08-4559
P407
P577
2009-06-01T00:00:00Z