Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.
about
When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitosesCyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progressionEvidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageThe decision to enter mitosis: feedback and redundancy in the mitotic entry networkLoss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balanceUBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentThe roles of cyclin A2, B1, and B2 in early and late mitotic eventsMicrotubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fateThe APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.When 2+2=5: the origins and fates of aneuploid and tetraploid cellsMaintaining Genome Stability in Defiance of Mitotic DNA DamageTargeting the Mitotic Catastrophe Signaling Pathway in CancerHitting the brakes: targeting microtubule motors in cancerDNA damage associated with mitosis and cytokinesis failureInhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cellsExpression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cellsThe 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsTumor treating fields perturb the localization of septins and cause aberrant mitotic exitA Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly CheckpointCell cycle checkpoint in cancer: a therapeutically targetable double-edged swordSpatiotemporal regulation of the anaphase-promoting complex in mitosisPolar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented ChromosomesStochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrestAurora-A kinase is essential for bipolar spindle formation and early developmentHSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancerCell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer CellsKnockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell divisionOverexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaThe APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitIdentification of genes that are essential to restrict genome duplication to once per cell divisionSpindle poisons and cell fate: a tale of two pathways.Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis.Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
P2860
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P2860
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mitotic checkpoint slippage in ...... esence of an active checkpoint
@nl
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@ast
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@en
type
label
Mitotic checkpoint slippage in ...... esence of an active checkpoint
@nl
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@ast
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@en
prefLabel
Mitotic checkpoint slippage in ...... esence of an active checkpoint
@nl
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@ast
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@en
P2860
P3181
P1433
P1476
Mitotic checkpoint slippage in ...... sence of an active checkpoint.
@en
P2093
Conly L Rieder
Daniela A Brito
P2860
P304
P3181
P356
10.1016/J.CUB.2006.04.043
P407
P577
2006-06-01T00:00:00Z