Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome - sprookjes - yvandenbroek - TriplyDB

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

http://www.wikidata.org/entity/Q24653357

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Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP)Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease Progress and problems in understanding and managing primary Epstein-Barr virus infections XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B Responses to Microbial Challenges by SLAMF Receptors Severe infectious diseases of childhood as monogenic inborn errors of immunity Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis T-regulatory cells in primary immune deficiencies X-linked lymphoproliferative syndromes: brothers or distant cousins?NK Cell Influence on the Outcome of Primary Epstein-Barr Virus Infection The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product Interaction domains: from simple binding events to complex cellular behavior Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling.Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.SLAM-family receptors: immune regulators with or without SAP-family adaptors.Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.Defective B cell responses in the absence of SH2D1A A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH).Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia.On guard--activating NK cell receptors.

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P2860

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

http://www.wikidata.org/entity/Q24653357

description

1998 nî lūn-bûn

@nan

1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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Inactivating mutations in an S ...... d lymphoproliferative syndrome

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A Bernard

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A J Buckler

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A T Look

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C Genovese

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D A Haber

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D E Housman

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D P Harkin

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E Snyder

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J Ashley

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K A Kolquist

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P2860

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions

Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl

Characterization of three overlapping deletions causing X-linked lymphoproliferative disease

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation

Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP

Regulation of second messengers by the inositol polyphosphate 5-phosphatases.

Mapping the X-linked lymphoproliferative syndrome

Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis

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13474536

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