Common mechanisms of PIKK regulation - sprookjes - yvandenbroek - TriplyDB

Common mechanisms of PIKK regulation

Common mechanisms of PIKK regulation

http://www.wikidata.org/entity/Q24653672

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Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair Multiple roles of ATM in monitoring and maintaining DNA integrity Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy ATR-mediated regulation of nuclear and cellular plasticity Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis Ataxia-telangiectasia: future prospects mTOR kinase structure, mechanism and regulation Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Systemic DNA damage responses in aging and diseases ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres Structures of closed and open conformations of dimeric human ATM Autophosphorylation and ATM activation: additional sites add to the complexity.Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2 Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1 The meiotic checkpoint network: step-by-step through meiotic prophase The ATM protein: the importance of being active.Structure of the human dimeric ATM kinase.The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.Replication stress induces 53BP1-containing OPT domains in G1 cells.Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.All stressed out without ATM kinase Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.

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P2860

Common mechanisms of PIKK regulation

http://www.wikidata.org/entity/Q24653672

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Common mechanisms of PIKK regulation

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Courtney A Lovejoy

http://www.w3.org/2001/XMLSchema#string

David Cortez

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P2860

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

ATMIN defines an NBS1-independent pathway of ATM signalling

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

Replication protein A-mediated recruitment and activation of Rad17 complexes

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

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