T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance - sprookjes - yvandenbroek - TriplyDB

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

http://www.wikidata.org/entity/Q24656282

about

Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner Disrupted regulatory T cell homeostasis in inflammatory bowel diseases Natural history of chronic hepatitis B virus infection from infancy to adult life - the mechanism of inflammation triggering and long-term impacts Balancing acts: the role of TGF-β in the mucosal immune system Development of thymic Foxp3(+) regulatory T cells: TGF-β matters Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4 Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming Cardiac deletion of Smyd2 is dispensable for mouse heart development RNA Interference and Cancer Therapy Spontaneous, immune-mediated gastric inflammation in SAMP1/YitFc mice, a model of Crohn's-like gastritis.TGF-β activation and function in immunity.PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors Cellular and molecular basis for the regulation of inflammation by TGF-beta.Identification of proprotein convertase substrates using genome-wide expression correlation analysis.Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.Regulatory T cells and immune tolerance in the intestine.Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis.GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation.EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion.Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo.Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression Loss of endothelial furin leads to cardiac malformation and early postnatal death.Generation and characterization of non-competitive furin-inhibiting nanobodies.Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.Foxp3 processing by proprotein convertases and control of regulatory T cell function.Peptide processing and biology in human disease.Signal transduction and Th17 cell differentiation.Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes.T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling.

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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

http://www.wikidata.org/entity/Q24656282

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

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name

T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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type

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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prefLabel

T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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T-cell-expressed proprotein co ...... of peripheral immune tolerance

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Anton Roebroek

http://www.w3.org/2001/XMLSchema#string

Ethan M Shevach

http://www.w3.org/2001/XMLSchema#string

Ivan Fuss

http://www.w3.org/2001/XMLSchema#string

John Creemers

http://www.w3.org/2001/XMLSchema#string

John J O'Shea

http://www.w3.org/2001/XMLSchema#string

Lai Wei

http://www.w3.org/2001/XMLSchema#string

Lili Xu

http://www.w3.org/2001/XMLSchema#string

Martha Quezado

http://www.w3.org/2001/XMLSchema#string

Warren Strober

http://www.w3.org/2001/XMLSchema#string

Wendy T Watford

http://www.w3.org/2001/XMLSchema#string

P2860

Furin at the cutting edge: from protein traffic to embryogenesis and disease

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

Making sense of latent TGFbeta activation

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

Curbing activation: proprotein convertases in homeostasis and pathology.

Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.

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246-250

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scholarly article

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2312727

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10.1038/NATURE07210

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7210

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455

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Yasmine Belkaid

Nicolas Bouladoux

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2008-09-01T00:00:00Z

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23169620

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1044939222

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18701887

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2758057

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