The promises and pitfalls of RNA-interference-based therapeutics - sprookjes - yvandenbroek - TriplyDB

The promises and pitfalls of RNA-interference-based therapeutics

The promises and pitfalls of RNA-interference-based therapeutics

http://www.wikidata.org/entity/Q24657247

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Role of exosomes/microvesicles in the nervous system and use in emerging therapies MicroRNA 329 suppresses angiogenesis by targeting CD146 Secretory mechanisms and intercellular transfer of microRNAs in living cells Microneedles As a Delivery System for Gene Therapy Cell Penetrating Peptide Conjugated Chitosan for Enhanced Delivery of Nucleic Acid Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy for Duchenne muscular dystrophy Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice The emergence of lncRNAs in cancer biology The role of DNA methylation in aging, rejuvenation, and age-related disease Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma Multiple exportins influence thyroid hormone receptor localization Hymyc1 downregulation promotes stem cell proliferation in Hydra vulgaris Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain Abasic pivot substitution harnesses target specificity of RNA interference The role of RNAi and microRNAs in animal virus replication and antiviral immunity Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides.New trends for overcoming ABCG2/BCRP-mediated resistance to cancer therapies RNA-targeted Therapeutics for ALS Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma Therapeutic genome editing: prospects and challenges Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles Reconsideration of in-silico siRNA design based on feature selection: a cross-platform data integration perspective EGFP-EGF1-conjugated PLGA nanoparticles for targeted delivery of siRNA into injured brain microvascular endothelial cells for efficient RNA interference siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats Human RGM249-derived small RNAs potentially regulate tumor malignancy Expression of multiple artificial microRNAs from a chicken miRNA126-based lentiviral vector Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials.Gene silencing: a therapeutic approach to combat influenza virus infections.Ultrasound-targeted microbubble destruction of calcium channel subunit α 1D siRNA inhibits breast cancer via G protein-coupled receptor 30 Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian influenza H5N1.Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor.Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver Sniffing for gene-silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: correlation between knockdown efficiency and sustainability of sirnas revealed by FRET-based probing In silico target-specific siRNA design based on domain transfer in heterogeneous data.siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.

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The promises and pitfalls of RNA-interference-based therapeutics

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2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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The promises and pitfalls of RNA-interference-based therapeutics

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Daniela Castanotto

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John J Rossi

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

Cellular cofactors affecting hepatitis C virus infection and replication

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

An endogenous small interfering RNA pathway in Drosophila

RNAi-mediated targeting of heterochromatin by the RITS complex

The impact of microRNAs on protein output

Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells

Functional polarity is introduced by Dicer processing of short substrate RNAs.

Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)

The response of mammalian cells to double-stranded RNA

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10.1038/NATURE07758

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457

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