Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
about
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrinsStructural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationFERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migrationSHARPIN is an endogenous inhibitor of β1-integrin activationChanges in single-molecule integrin dynamics linked to local cellular behavior.Kindlin-1 regulates integrin dynamics and adhesion turnoverMolecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell AdhesionThe Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationMechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin ActivationCrystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationBiology and structure of leukocyte β 2 integrins and their role in inflammationA computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activationC-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytesThe integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafishDistinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo.Diverse integrin adhesion stoichiometries caused by varied actomyosin activity.Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.New insights into the versatile roles of platelet FlnA.Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.Talins and kindlins: partners in integrin-mediated adhesion.Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.The final steps of integrin activation: the end gameTyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activationSpatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tailsZasp regulates integrin activation.A role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axisThe tail of integrin activation.Analysis of conserved residues in the betapat-3 cytoplasmic tail reveals important functions of integrin in multiple tissues.Endothelial destabilization by angiopoietin-2 via integrin β1 activation.Cooperativity between integrin activation and mechanical stress leads to integrin clustering.Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.
P2860
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P2860
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@ast
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@en
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@nl
type
label
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@ast
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@en
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@nl
prefLabel
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@ast
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@en
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@nl
P2093
P2860
P3181
P356
P1476
Kindlin-1 and -2 directly bind ...... in-specific activation effects
@en
P2093
David A Calderwood
David S Harburger
Mohamed Bouaouina
P2860
P304
P3181
P356
10.1074/JBC.M809233200
P407
P577
2009-04-24T00:00:00Z