Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis - sprookjes - yvandenbroek - TriplyDB

Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

http://www.wikidata.org/entity/Q24669763

about

Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis Honokiol, a multifunctional antiangiogenic and antitumor agent Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity Honokiol: a novel natural agent for cancer prevention and therapy Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis Protective effect of berberine against oxidative stress-induced apoptosis in rat bone marrow-derived mesenchymal stem cells.Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis.Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.Potential of plant-derived natural products in the treatment of leukemia and lymphoma The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds.Pathway-based identification of SNPs predictive of survival Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo.Honokiol is a potent scavenger of superoxide and peroxyl radicals.Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells.The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways.The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.Antineoplastic Effects of Honokiol on Melanoma.Small mitochondria-targeting molecules as anti-cancer agents.Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways.Mitochondrial metabolism inhibitors for cancer therapy.Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.Compounds from Chinese herbal medicines as reversal agents for P-glycoprotein-mediated multidrug resistance in tumours.Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies.HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies.The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence.Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (III).In vitro growth inhibition of human cancer cells by novel honokiol analogs.Antimetastatic activity of honokiol in osteosarcoma.Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells.Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells.Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model.Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model.Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol.

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Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

http://www.wikidata.org/entity/Q24669763

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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type

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Honokiol overcomes conventiona ...... ent and -independent apoptosis

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Aldo M Roccaro

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Dharminder Chauhan

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Hiromasa Hideshima

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Hiroshi Yasui

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Jack Arbiser

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Kazuo Tamura

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Kenji Ishitsuka

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Klaus Podar

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Makoto Hamasaki

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Noopur Raje

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P2860

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

Heat shock proteins--modulators of apoptosis in tumour cells

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma.

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1794-800

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scholarly article

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1424165

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10.1182/BLOOD-2005-01-0346

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5

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Kenneth C Anderson

Paul G Richardson

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2005-09-01T00:00:00Z

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7868571

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15870175

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apoptotic process

multiple drug resistance

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1895215

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