RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection - sprookjes - yvandenbroek - TriplyDB

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

http://www.wikidata.org/entity/Q24671766

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Novel role of PKR in inflammasome activation and HMGB1 release Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development Expression and cellular localization of microRNA-29b and RAX, an activator of the RNA-dependent protein kinase (PKR), in the retina of streptozotocin-induced diabetic rats PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.A Toll-like receptor-responsive kinase, protein kinase R, is inactivated in endotoxin tolerance through differential K63/K48 ubiquitination.The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin dsRNA binding protein PACT/RAX in gene silencing, development and diseases.Altered regulation of ELAVL1/HuR in HLA-B27-expressing U937 monocytic cells.PACT/RAX regulates the migration of cerebellar granule neurons in the developing cerebellum.Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT.PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.RAX is required for fly neuronal development and mouse embryogenesis.Decoding dangerous death: how cytotoxic chemotherapy invokes inflammation, immunity or nothing at all.TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.Lenalidomide and its role in the management of multiple myeloma.PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease Inherited predisposition to chronic lymphocytic leukemia mRNA decapping enzyme 1a (Dcp1a)-induced translational arrest through protein kinase R (PKR) activation requires the N-terminal enabled vasodilator-stimulated protein homology 1 (EVH1) domain.The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2.ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element.Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart.PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division.The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest Interaction between PKR and PACT mediated by LPS-inducible NF-κB in human gingival cells.Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy.Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness.PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis.Deriving at candidate genes of metabolic stress from pancreas of WNIN/GR-Ob mutant rats.Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.Increased interaction between PACT molecules in response to stress signals is required for PKR activation.Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

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RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

http://www.wikidata.org/entity/Q24671766

description

2006 nî lūn-bûn

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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի օգոստոսին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

name

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@ast

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@en

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@nl

type

label

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@ast

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@en

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@nl

prefLabel

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@ast

RAX, the PKR activator, sensit ...... motherapy, and viral infection

@en

RAX, the PKR activator, sensit ...... motherapy, and viral infection

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BLOOD-2005-11-006817

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RAX, the PKR activator, sensit ...... motherapy, and viral infection

@en

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Dean M Abtahi

http://www.w3.org/2001/XMLSchema#string

Richard L Bennett

http://www.w3.org/2001/XMLSchema#string

Sue A Moyer

http://www.w3.org/2001/XMLSchema#string

W Stratford May

http://www.w3.org/2001/XMLSchema#string

Yu Pan

http://www.w3.org/2001/XMLSchema#string

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Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

PACT, a protein activator of the interferon-induced protein kinase, PKR.

TRAF family proteins link PKR with NF-kappa B activation

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)

FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity.

Modular structure of PACT: distinct domains for binding and activating PKR

Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?

PKR; a sentinel kinase for cellular stress

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10.1182/BLOOD-2005-11-006817

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3

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William Blalock

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