Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
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Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on FenobamAdvances in the treatment of fragile X syndromeDiscovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonistsInfluence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autismAllosteric modulation of metabotropic glutamate receptors.Metabotropic glutamate receptors: from the workbench to the bedside.Advances in the treatment of anxiety: targeting glutamate.Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats.Metabotropic glutamate receptors: novel targets for pain relief.Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.Psychotherapeutic benefits of opioid agonist therapy.mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autismElevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depressionThe mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice.The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEPPreparation of a Series of 5-Methyl-3-(substituted)-[1,2,4]triazines.Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies.The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substratesThe effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology.Therapeutic potential of metabotropic glutamate receptor modulators.Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonistsGABA and glutamate systems as therapeutic targets in depression and mood disorders.Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.Innovative approaches for the development of antidepressant drugs: current and future strategiesNeural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targetsNovel Glutamatergic Treatments for Severe Mood Disorders.Are compounds acting at metabotropic glutamate receptors the answer to treating depression?Alteration by p11 of mGluR5 localization regulates depression-like behaviors.Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEPThe Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related DisordersCharacterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688Therapeutic Modulation of Glutamate Receptors in Major Depressive DisorderMetabotropic glutamate receptor subtype 5 antagonism in learning and memory.Investigational NMDA receptor modulators for depression.New perspectives on glutamate receptor antagonists as antidepressants.
P2860
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P2860
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@ast
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@en
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@nl
type
label
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@ast
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@en
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@nl
prefLabel
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@ast
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@en
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@nl
P2093
P2860
P356
P1476
Potential anxiolytic- and anti ...... tive mGlu5 receptor antagonist
@en
P2093
A Klodzińska
E Chojnacka-Wójcik
E Tatarczyńska
F Gasparini
P2860
P304
P356
10.1038/SJ.BJP.0703923
P407
P50
P577
2001-04-01T00:00:00Z