Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
about
Innate immunity and intestinal microbiota in the development of Type 1 diabetesDeletional tolerance mediated by extrathymic Aire-expressing cellsFoxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionThe cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesT cell epitopes and post-translationally modified epitopes in type 1 diabetesPredominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cellsCellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Glucose-6-phosphatase catalytic subunit gene familyThe contributions of mass spectrometry to understanding of immune recognition by T lymphocytes.Using a baculovirus display library to identify MHC class I mimotopes.Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands.Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.Peripherin-reactive antibodies in mouse, rabbit, and human blood.Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cellsMoving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.Insulin as a key autoantigen in the development of type 1 diabetesIns2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes.Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes.Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammationThe pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach.The central role of antigen presentation in islets of Langerhans in autoimmune diabetesCompensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responsesT cells recognizing a peptide contaminant undetectable by mass spectrometry.ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditionsDemonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cellsAntigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons.Mapping I-A(g7) restricted epitopes in murine G6PC2.A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
P2860
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P2860
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Identification of the beta cel ...... T cells in autoimmune diabetes
@nl
Identification of the beta cel ...... cells in autoimmune diabetes.
@ast
Identification of the beta cel ...... cells in autoimmune diabetes.
@en
type
label
Identification of the beta cel ...... T cells in autoimmune diabetes
@nl
Identification of the beta cel ...... cells in autoimmune diabetes.
@ast
Identification of the beta cel ...... cells in autoimmune diabetes.
@en
prefLabel
Identification of the beta cel ...... T cells in autoimmune diabetes
@nl
Identification of the beta cel ...... cells in autoimmune diabetes.
@ast
Identification of the beta cel ...... cells in autoimmune diabetes.
@en
P2093
P2860
P356
P1476
Identification of the beta cel ...... cells in autoimmune diabetes.
@en
P2093
Anne M Evans
Bingye Han
David V Serreze
Donald F Hunt
Jennifer A Caldwell
Pere Santamaria
Scott M Lieberman
Stanley G Nathenson
Teresa P DiLorenzo
Toshiyuki Takaki
P2860
P304
P356
10.1073/PNAS.0932778100
P407
P577
2003-06-18T00:00:00Z