TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
about
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative diseaseRapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease.Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicityPerispinal etanercept: potential as an Alzheimer therapeuticPerispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanismEmerging Link between Alzheimer's Disease and Homeostatic Synaptic PlasticityAlzheimer's Disease: Exploring the Role of Inflammation and Implications for TreatmentA Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in DiseaseExcess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agentsAmyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's diseaseRapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration.Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging.Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brainsTumor necrosis factor α Inhibition for Alzheimer's Disease.The meteorology of cytokine storms, and the clinical usefulness of this knowledgePerispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidenceInhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease.Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases.TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosisTumor necrosis factor alpha maintains denervation-induced homeostatic synaptic plasticity of mouse dentate granule cellsThe Role of Th17 in Neuroimmune Disorders: A Target for CAM Therapy. Part IIIAblation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model.Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge.Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trialTNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's diseaseMathematical model on Alzheimer's diseaseIdentification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases.Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammationPresent and prospective clinical therapeutic regimens for Alzheimer's disease.Construction of AAV-rat-IL4 and Evaluation of its Modulating Effect on Aβ (1-42)-Induced Proinflammatory Cytokines in Primary Microglia and the B92 Cell Line by Quantitative PCR AssayAge-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid.Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD miceIs TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?Cytokine Therapies in Neurological Disease.Therapeutic strategies for tau mediated neurodegeneration.The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer's Disease.
P2860
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P2860
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
description
2006 nî lūn-bûn
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2006 թուականին հրատարակուած գիտական յօդուած
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2006 թվականին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@ast
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@en
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
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type
label
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@ast
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@en
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@nl
prefLabel
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@ast
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@en
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@nl
P2093
P2860
P3181
P1476
TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study
@en
P2093
Alan Weinberger
Edward Tobinick
Hart Cohen
Hyman Gross
P2860
P3181
P407
P577
2006-04-26T00:00:00Z