Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP
about
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivoThe human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosomeCharacterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box proteinHuman splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivoFunctional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNAThe pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling proteinA novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNADomains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formationThe ASRG database: identification and survey of Arabidopsis thaliana genes involved in pre-mRNA splicingStructure and assembly of the SF3a splicing factor complex of U2 snRNPMicrobial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentU2AF participates in the binding of TAP (NXF1) to mRNAStructural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density mapsThe ATP requirement for U2 snRNP addition is linked to the pre-mRNA region 5' to the branch site.Nuclear fibroblast growth factor-2 interacts specifically with splicing factor SF3a66Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediateRearrangements within human spliceosomes captured after exon ligation.Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation.Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytesThe anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing.ATP can be dispensable for prespliceosome formation in yeastRegulation of toll-like receptor signaling by the SF3a mRNA splicing complex.U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingNuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.The interaction of Prp2 with a defined region of the intron is required for the first splicing reaction.Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.WSTF does it all: a multifunctional protein in transcription, repair, and replication.Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.Cajal bodies and snRNPs - friends with benefits.Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Biological validation that SF3b is a target of the antitumor macrolide pladienolide.In situ transcription and splicing in the Balbiani ring 3 gene.
P2860
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P2860
Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@ast
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@en
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@nl
type
label
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@ast
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@en
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@nl
prefLabel
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@ast
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@en
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@nl
P2093
P2860
P3181
P356
P1476
Combined biochemical and elect ...... ture of the mammalian U2 snRNP
@en
P2093
P2860
P304
P3181
P356
10.1083/JCB.145.7.1355
P407
P577
1999-06-28T00:00:00Z