Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
about
Very important pharmacogene summary: thiopurine S-methyltransferasePharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical UseNUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicityDrug methylation in cancer therapy: lessons from the TPMT polymorphismFrequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositusNew genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acidMolecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic LeukemiaFour human thiopurine s-methyltransferase alleles severely affect protein structure and dynamicsThiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation.Thiopurine S-methyltransferase pharmacogenetics: functional characterization of a novel rapidly degraded variant allozyme.Polymorphisms and disease: hotspots of inactivation in methyltransferasesPharmacogenetics of cancer therapy: getting personalInherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.Recent advances in the pharmacogenomics of thiopurine methyltransferase.The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Pharmacogenetics in diverse ethnic populations--implications for drug discovery and development.Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population.The emergence of resistance to targeted cancer therapeutics.A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.Pharmacogenomics: marshalling the human genome to individualise drug therapyCancer pharmacogenomics: SNPs, chips, and the individual patient.Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines.Pharmacogenomics: bench to bedside.Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug eventsThiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.Pharmacogenetics and diseases of the colon.The role of pharmacogenetics in cancer therapeutics.Genetic variants and the risk of Crohn's disease: what does it mean for future disease management?Review article: thiopurines in inflammatory bowel disease.Clinical application of pharmacogenetics in gastrointestinal diseases.The pharmacogenetics research network: from SNP discovery to clinical drug response.Nomenclature for alleles of the thiopurine methyltransferase gene.Pharmacogenetics of drug metabolizing enzymes and transporters: effects on pharmacokinetics and pharmacodynamics of anticancer agents.PhRMA white paper on ADME pharmacogenomics.Gene polymorphisms and pharmacogenetics in rheumatoid arthritisPart 1: background, methodology, and clinical adoption of pharmacogenetics.Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism.
P2860
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P2860
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@ast
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@en
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@nl
type
label
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@ast
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@en
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@nl
prefLabel
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@ast
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@en
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@nl
P2093
P2860
P3181
P356
P1476
Enhanced proteolysis of thiopu ...... polymorphism of TPMT activity
@en
P2093
E G Schuetz
E Y Krynetski
Y Yanishevski
P2860
P304
P3181
P356
10.1073/PNAS.94.12.6444
P407
P577
1997-06-10T00:00:00Z