SPDEF regulates goblet cell hyperplasia in the airway epithelium
about
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lungA nonredundant role for mouse Serpinb3a in the induction of mucus production in asthmaRegeneration of the lung: Lung stem cells and the development of lung mimicking devicesIL-4 and IL-13 signaling in allergic airway diseaseThe cell biology of asthmaSPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus productionFoxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium.Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPDThe ER stress transducer IRE1β is required for airway epithelial mucin productionLung epithelial stem cells and their niches: Fgf10 takes center stage.Aldose reductase inhibition prevents metaplasia of airway epithelial cells.Does Inhalation of Virgin Coconut Oil Accelerate Reversal of Airway Remodelling in an Allergic Model of Asthma?Mouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4.Developmental programs of lung epithelial progenitors: a balanced progenitor model.Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.Myb permits multilineage airway epithelial cell differentiation.A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia.Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammationIntersections between pulmonary development and disease.High SPDEF may identify patients who will have a prolonged response to androgen deprivation therapy.Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary diseaseAirway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasiaThe SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression.The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge.Wheezing and itching: The requirement for STAT proteins in allergic inflammationGlucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunitySpdef null mice lack conjunctival goblet cells and provide a model of dry eye.
P2860
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P2860
SPDEF regulates goblet cell hyperplasia in the airway epithelium
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@ast
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@en
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@nl
type
label
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@ast
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@en
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@nl
prefLabel
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@ast
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@en
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@nl
P2093
P2860
P3181
P356
P1476
SPDEF regulates goblet cell hyperplasia in the airway epithelium
@en
P2093
Huajing Wan
Jeffrey A Whitsett
Joseph A Kitzmiller
Kwon-Sik Park
Michael D Bruno
Susan E Wert
Thomas R Korfhagen
P2860
P304
P3181
P356
10.1172/JCI29176
P407
P577
2007-04-01T00:00:00Z