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Increased islet apoptosis in Pdx1+/- mice

Increased islet apoptosis in Pdx1+/- mice

http://www.wikidata.org/entity/Q24683719

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RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis miR-375 maintains normal pancreatic alpha- and beta-cell mass Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome Mechanisms of action of glucagon-like peptide 1 in the pancreas Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.Genes involved in pancreatic islet cell rejuvenation Molecular mechanisms that differentiate apoptosis from programmed necrosis Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology Statistical approaches and software for clustering islet cell functional heterogeneity.Sox17 regulates insulin secretion in the normal and pathologic mouse β cell Natural history of β-cell adaptation and failure in type 2 diabetes Control of insulin secretion by cytochrome C and calcium signaling in islets with impaired metabolism Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction Absence of a reductase, NCB5OR, causes insulin-deficient diabetes The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2 Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.High-content screening identifies a role for Na(+) channels in insulin production Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors MicroRNAs in adipogenesis and as therapeutic targets for obesity.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Obesity and type 2 diabetes: what can be unified and what needs to be individualized?Calcium release channel RyR2 regulates insulin release and glucose homeostasis Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats.Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons Plant-Produced Asialo-Erythropoietin Restores Pancreatic Beta-Cell Function by Suppressing Mammalian Sterile-20-like Kinase (MST1) and Caspase-3 Activation PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

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P2860

Increased islet apoptosis in Pdx1+/- mice

http://www.wikidata.org/entity/Q24683719

description

2003 nî lūn-bûn

@nan

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

name

Increased islet apoptosis in Pdx1+/- mice

@ast

Increased islet apoptosis in Pdx1+/- mice

@en

Increased islet apoptosis in Pdx1+/- mice

@nl

type

label

Increased islet apoptosis in Pdx1+/- mice

@ast

Increased islet apoptosis in Pdx1+/- mice

@en

Increased islet apoptosis in Pdx1+/- mice

@nl

prefLabel

Increased islet apoptosis in Pdx1+/- mice

@ast

Increased islet apoptosis in Pdx1+/- mice

@en

Increased islet apoptosis in Pdx1+/- mice

@nl

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Journal of Clinical Investigation

P1476

Increased islet apoptosis in Pdx1+/- mice

@en

P2093

Hung Tran

http://www.w3.org/2001/XMLSchema#string

James D Johnson

http://www.w3.org/2001/XMLSchema#string

Jun Fujita

http://www.w3.org/2001/XMLSchema#string

Kenneth S Polonsky

http://www.w3.org/2001/XMLSchema#string

Noreen T Ahmed

http://www.w3.org/2001/XMLSchema#string

Stanley Misler

http://www.w3.org/2001/XMLSchema#string

Zhiqiang Han

http://www.w3.org/2001/XMLSchema#string

P2860

Compromised HOXA5 function can limit p53 expression in human breast tumours

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Method for the isolation of intact islets of Langerhans from the rat pancreas

The Hox11 gene is essential for cell survival during spleen development

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

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1147-60

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124773

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10.1172/JCI16537

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10.1172/JCI200316537

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12697734

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apoptotic process

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152933

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