Autoregulation of the Raf-1 serine/threonine kinase - sprookjes - yvandenbroek - TriplyDB

Autoregulation of the Raf-1 serine/threonine kinase

Autoregulation of the Raf-1 serine/threonine kinase

http://www.wikidata.org/entity/Q24684153

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Raf family kinases: old dogs have learned new tricks Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain Regulation of protein kinases by lipids Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum Regulation of Raf through phosphorylation and N terminus-C terminus interaction Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1 B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)A different function for a critical tryptophan in c-Raf and Hck.Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.Insight into molecular dynamics simulation of BRAF(V600E) and potent novel inhibitors for malignant melanoma Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition Raf kinases: function, regulation and role in human cancer.Targeting the PI3K and MAPK pathways to treat Kaposi's-sarcoma-associated herpes virus infection and pathogenesis.BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling.Mechanistic principles of RAF kinase signaling.Tumor adaptation and resistance to RAF inhibitors.A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation and cell cycle arrest.Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition.Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis.Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.Raf-1 regulates Rho signaling and cell migration.From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity.Protein kinase D activation by deletion of its cysteine-rich motifs.

P2860

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P2860

Autoregulation of the Raf-1 serine/threonine kinase

http://www.wikidata.org/entity/Q24684153

description

1998 nî lūn-bûn

@nan

1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

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1998年論文

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1998年论文

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name

Autoregulation of the Raf-1 serine/threonine kinase

@ast

Autoregulation of the Raf-1 serine/threonine kinase

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Autoregulation of the Raf-1 serine/threonine kinase

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type

label

Autoregulation of the Raf-1 serine/threonine kinase

@ast

Autoregulation of the Raf-1 serine/threonine kinase

@en

Autoregulation of the Raf-1 serine/threonine kinase

@nl

prefLabel

Autoregulation of the Raf-1 serine/threonine kinase

@ast

Autoregulation of the Raf-1 serine/threonine kinase

@en

Autoregulation of the Raf-1 serine/threonine kinase

@nl

P1433

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PNAS.95.16.9214

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Autoregulation of the Raf-1 serine/threonine kinase

@en

P2093

D K Morrison

http://www.w3.org/2001/XMLSchema#string

M R Saracino

http://www.w3.org/2001/XMLSchema#string

R E Cutler

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R M Stephens

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P2860

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

Mammalian Ras interacts directly with the serine/threonine kinase Raf

MAP kinase pathways in yeast: for mating and more.

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

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9214-9

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scholarly article

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10.1073/PNAS.95.16.9214

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P433

16

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95

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1998-08-04T00:00:00Z

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13596283

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9689060

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21318

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