A specific interface between integrin transmembrane helices and affinity for ligand
about
Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingMigfilin, a molecular switch in regulation of integrin activationStructure and function of the platelet integrin alphaIIbbeta3Integrin bidirectional signaling: a molecular viewStructural organization and interactions of transmembrane domains in tetraspanin proteinsSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenStructure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesStructure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationα(V)β(3) integrin crystal structures and their functional implicationsIntegrin α1 Has a Long Helix, Extending from the Transmembrane Region to the Cytoplasmic Tail in Detergent MicellesComplete integrin headpiece opening in eight stepsThree-dimensional reconstruction of intact human integrin IIb 3: new implications for activation-dependent ligand bindingCell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinityStructural basis of integrin regulation and signalingFocal adhesions are sites of integrin extension.How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation.Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.UVB-irradiation regulates VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 under flow conditions.Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling.Recreation of the terminal events in physiological integrin activation.Consensus motif for integrin transmembrane helix associationStructural basis of transmembrane domain interactions in integrin signaling.Intermolecular transmembrane domain interactions activate integrin αIIbβ3.The final steps of integrin activation: the end gameSpecificity for homooligomer versus heterooligomer formation in integrin transmembrane helicesTransmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).Integrin αIIb-mediated PI3K/Akt activation in platelets.Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingWhy integrin as a primary target for imaging and therapy.CW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomesTransmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesConserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replicationMultiscale simulations suggest a mechanism for integrin inside-out activation.Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeuticsIntegrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane.Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.Talin activates integrins by altering the topology of the β transmembrane domainRequirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
P2860
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P2860
A specific interface between integrin transmembrane helices and affinity for ligand
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A specific interface between integrin transmembrane helices and affinity for ligand
@ast
A specific interface between integrin transmembrane helices and affinity for ligand
@en
A specific interface between integrin transmembrane helices and affinity for ligand
@nl
type
label
A specific interface between integrin transmembrane helices and affinity for ligand
@ast
A specific interface between integrin transmembrane helices and affinity for ligand
@en
A specific interface between integrin transmembrane helices and affinity for ligand
@nl
prefLabel
A specific interface between integrin transmembrane helices and affinity for ligand
@ast
A specific interface between integrin transmembrane helices and affinity for ligand
@en
A specific interface between integrin transmembrane helices and affinity for ligand
@nl
P2093
P2860
P1433
P1476
A specific interface between integrin transmembrane helices and affinity for ligand
@en
P2093
Bing-Hao Luo
Junichi Takagi
Timothy A Springer
P2860
P356
10.1371/JOURNAL.PBIO.0020153
P407
P577
2004-06-01T00:00:00Z