Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
about
Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosisFoxO1 and SIRT1 regulate beta-cell responses to nitric oxideThe unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping dataMyt3 Mediates Laminin-V/Integrin-β1-Induced Islet-Cell Migration via TgfbiRegulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.Small G proteins in islet beta-cell function.A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets.Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal pIslet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation.Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell linesHMGB1 in health and disease.Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomesHow the location of superoxide generation influences the β-cell response to nitric oxide.CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation.NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells.A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell deathLarge-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes.Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.Cytokine-mediated β-cell damage in PARP-1-deficient islets.IL-1 family cytokines trigger sterile inflammatory disease.Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stabilityalpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in miceToll-like receptor signaling in transplantation.Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.Do β-cells generate peroxynitrite in response to cytokine treatment?Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage.Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes.NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription.Pdx1 and other factors that regulate pancreatic beta-cell survival.HMGB1-LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotypeAnti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.
P2860
Q28476371-E2446B1F-670A-4BA2-8BE1-FC9F9D124C77Q28589190-BDCBE790-6F7F-4BAB-A060-9D784B159324Q30435990-CDD4FF7E-6527-4764-89D1-930B03EF62A5Q33399896-A916A9CF-4D2D-45DA-927B-1E4860AAC3F4Q33631551-33F4315A-1E69-4041-B49B-D3AAAB3774A2Q33669239-FCE60888-98C0-404C-907A-DAA3EEFE02D4Q33779672-465F7D94-5294-4D88-B241-2D95A0AF22DAQ33949177-A1968FF7-D671-4C85-889E-585BB31CCC3EQ33954575-C7481D3B-3148-4A4C-ABB7-0D76FE10C00DQ33987148-362F8D8E-5FD9-4EC5-850B-427663521865Q34135391-23D28243-337F-4348-8954-6E2FF70484D1Q34146626-4F14B93E-DD14-4662-BA60-A321F073080CQ34622835-FCF8C62F-C98D-4547-BF88-98834F2556BDQ35035258-FF71148D-739A-4AE0-A135-809C41250E41Q35199487-E6CA409C-53FF-4216-972D-47F85A6C7830Q35200250-F52C4B24-524E-44AB-B486-7E066EC17B47Q35310273-C93742A1-ECE6-4B95-B49E-7B49BDCCD321Q35525740-DB82F44D-5478-4BA2-8D45-E8F313ACEDCAQ35612451-E2B7AC1E-BFBE-4851-BF93-82BA959F6FE0Q35832660-FB11BA2E-278F-4290-B2BD-C84B618FDC63Q36041872-7C7D2806-ED6A-475F-A218-2D8C4639C0B0Q36060484-23433131-DA90-43D0-A5F8-70C38503EFD3Q36114154-18515F6C-7BB3-4284-84AF-F948E1444024Q36200224-C500A7EC-CA45-4B0A-8C31-66AF3F4F5298Q36304279-558103AA-68E6-4892-8754-ABFBF14CE74CQ36347351-CB506296-0FAC-481A-AFF5-F859AA753267Q36935759-0C5AB3A4-27B0-4B7B-B2DE-637FDA00A3A0Q37236946-6837CEA9-BEA5-4F56-92D4-CCD931CF9209Q37275113-3D12F696-D3F9-4369-A60E-89E9BC77A7F4Q37405043-142A73E8-CC8E-4E32-86C3-7F604ABC0167Q37430834-885C5CE6-3AF1-4D85-B594-C3FB1CED04E8Q37448040-7ACC8440-65CF-4D06-9003-963055A93869Q37466399-A5A5DE2E-9071-48A7-8180-1E937DDFA233Q37560287-DC6AC546-F38C-4D4B-B0FA-C18696E9177BQ37575397-AC43D295-89B1-4AAD-8DC6-5E560A7D3116Q37611922-4CCC5D76-30DA-40C2-A53B-89FA5B63E210Q37620697-F3706295-D8BF-47B8-96F9-75BC3A18637FQ37667018-6A41A239-9C18-49AE-BE79-7F81EB77B997Q38074472-E9BF154C-8357-4518-8510-228AA45DCA44Q38184888-ACE5E4C4-1D76-4CE3-9BB6-0E07A24494A3
P2860
Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@ast
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@en
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@nl
type
label
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@ast
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@en
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@nl
prefLabel
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@ast
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@en
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@nl
P2093
P2860
P1433
P1476
Interleukin-1 stimulates beta- ...... e immunological adjuvant HMGB1
@en
P2093
Anna L Scarim
John A Corbett
Kari T Chambers
Sarah A Steer
P2860
P356
10.1371/JOURNAL.PMED.0030017
P407
P577
2005-12-20T00:00:00Z