Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity - sprookjes - yvandenbroek - TriplyDB

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

http://www.wikidata.org/entity/Q25256506

about

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 Animal models of Parkinson's disease: vertebrate genetics Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.Identification and characterization of a novel endogenous murine parkin mutation.Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.Transgenic animal models of neurodegeneration based on human genetic studies.Microarrays in Parkinson's disease: a systematic approach.Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Parkin deficiency increases vulnerability to inflammation-related nigral degeneration Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies.Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance.Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.The role of parkin in familial and sporadic Parkinson's disease.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Oxidative stress in genetic mouse models of Parkinson's disease.Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases.Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease.Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain.Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity.Parkin-knockout mice did not display increased vulnerability to intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.Comparative analysis of Parkinson's disease-associated genes reveals altered survival and bioenergetics of parkin-deficient dopamine neurons in mice.PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect

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P2860

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

http://www.wikidata.org/entity/Q25256506

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

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2005年論文

@zh-tw

2005年论文

@wuu

name

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@ast

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@en

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@nl

type

label

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@ast

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@en

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@nl

prefLabel

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@ast

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@en

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

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BMC Neuroscience

P1476

Parkin-deficient mice are not ...... methamphetamine neurotoxicity

@en

P2093

Francisco A Perez

http://www.w3.org/2001/XMLSchema#string

Richard D Palmiter

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Wendy R Curtis

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P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

A role for dopamine in feeding responses produced by orexigenic agents

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

Bacterial senescence: protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes

Parkin-deficient mice are not a robust model of parkinsonism.

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