Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
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Propagation of prions causing synucleinopathies in cultured cellsDefinition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationNative α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Dynamic structural flexibility of α-synucleinPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Biophysical characterization of α-synuclein and its controversial structureThe Synaptic Function of α-SynucleinThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseInvestigation of intramolecular dynamics and conformations of α-, β- and γ-synucleinSynucleins regulate the kinetics of synaptic vesicle endocytosis.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synucleinAlpha-synuclein function and dysfunction on cellular membranes.Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicityOverexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).α-Synuclein and mitochondria: partners in crime?Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegenerationStructural basis of synaptic vesicle assembly promoted by α-synuclein.TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.The Synucleinopathies: Twenty Years On.Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.Phenotypic screens targeting neurodegenerative diseases.The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.Monoamine oxidase and α-synuclein as targets in Parkinson's disease therapy.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Synaptic failure and α-synuclein.A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Early synaptic dysfunction in Parkinson's disease: Insights from animal models.Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivoCell Biology and Pathophysiology of α-Synuclein.
P2860
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P2860
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Systematic mutagenesis of α-sy ...... al and pathological activities
@ast
Systematic mutagenesis of α-sy ...... al and pathological activities
@en
Systematic mutagenesis of α-sy ...... al and pathological activities
@nl
type
label
Systematic mutagenesis of α-sy ...... al and pathological activities
@ast
Systematic mutagenesis of α-sy ...... al and pathological activities
@en
Systematic mutagenesis of α-sy ...... al and pathological activities
@nl
prefLabel
Systematic mutagenesis of α-sy ...... al and pathological activities
@ast
Systematic mutagenesis of α-sy ...... al and pathological activities
@en
Systematic mutagenesis of α-sy ...... al and pathological activities
@nl
P2860
P3181
P1476
Systematic mutagenesis of α-sy ...... al and pathological activities
@en
P2093
Manu Sharma
P2860
P304
P3181
P356
10.1523/JNEUROSCI.3545-12.2012
P407
P577
2012-10-24T00:00:00Z