A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? - sprookjes - yvandenbroek - TriplyDB

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

http://www.wikidata.org/entity/Q26269969

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Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse Neurotransmitter release: the last millisecond in the life of a synaptic vesicle The presynaptic active zone RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7 Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13 RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch Sumoylation in Synaptic Function and Dysfunction Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone Functions of Rab Proteins at Presynaptic Sites The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins Structures and mechanisms of vesicle coat components and multisubunit tethering complexes Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3 Munc13-1 is required for presynaptic long-term potentiation Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Characterization of Munc13-1 and insulin secretion during pancreatic development in rats.Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography.Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions At the junction of SNARE and SM protein function.Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Calcium regulates vesicle replenishment at the cone ribbon synapse.Studying synaptic efficiency by post-hoc immunolabelling.Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.

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A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

http://www.wikidata.org/entity/Q26269969

description

2005 nî lūn-bûn

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2005 թվականի օգոստոսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@ast

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@en

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@nl

type

label

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

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A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@en

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@nl

prefLabel

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@ast

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

@en

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

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SJ.EMBOJ.7600753

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The EMBO Journal

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A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

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Amer Alam

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Irina Dulubova

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Iryna Huryeva

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Jun Lu

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Ralf Schneggenburger

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Xuelin Lou

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P2860

A conformational switch in syntaxin during exocytosis: role of munc18.

The presynaptic active zone protein RIM1alpha is critical for normal learning and memory.

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rab proteins as membrane organizers

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

Drosophila UNC-13 is essential for synaptic transmission

Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone

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2839-50

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10.1038/SJ.EMBOJ.7600753

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16

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24

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Thomas C. Südhof

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7694001

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16052212

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1187938

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