What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway
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Emerging molecular classifications and therapeutic implications for gastric cancerRedox Control of Multidrug Resistance and Its Possible Modulation by AntioxidantsPhase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors.The therapeutic potential of targeting the PI3K pathway in pediatric brain tumorsFAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistanceTargeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?mTOR signaling in tumorigenesisComputer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunitiesPI3K and cancer: lessons, challenges and opportunitiesSynergistic interactions with PI3K inhibition that induce apoptosis.Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphomaMYC-xing it up with PIK3CA mutation and resistance to PI3K inhibitors: summit of two giants in breast cancersNanomicellar TGX221 blocks xenograft tumor growth of prostate cancer in nude mice.Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.Empirical inference of circuitry and plasticity in a kinase signaling networkGlucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays.Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitorsIdentifying therapeutic targets in gastric cancer: the current status and future directionDecreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.Translational and clinical implications of the genetic landscape of prostate cancer.Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells.Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinomaAnticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine.Role of phosphoproteomics in the development of personalized cancer therapies.Clinical management of breast cancer heterogeneity.Drugging PI3K in cancer: refining targets and therapeutic strategiesApproaches to identify kinase dependencies in cancer signalling networks.Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas.Pharmacogenomics of Scopoletin in Tumor Cells.Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion.Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy.Predictive biomarkers along gastric cancer pathogenetic pathways.The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review).G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway.
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P2860
What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway
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2013 nî lūn-bûn
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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
@ast
What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
@en
What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
@nl
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
@ast
What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
@en
What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
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What a tangled web we weave: e ...... sphoinositide 3-kinase pathway
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Andrea P Myers
P2860
P304
P3181
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10.1158/2159-8290.CD-13-0063
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P577
2013-12-01T00:00:00Z