Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists
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The endogenous nociceptin/orphanin FQ-NOP receptor system as a potential therapeutic target for intestinal disordersDistinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism.Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.Injury-Dependent and Disability-Specific Lumbar Spinal Gene Regulation following Sciatic Nerve Injury in the RatNeuraxial opioid-induced itch and its pharmacological antagonismPharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeysCharacterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo).Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys.Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthmaCentral N/OFQ-NOP Receptor System in Pain Modulation.Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in micePharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonistCebranopadol : a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors.Clinical Pharmacokinetic Characteristics of Cebranopadol, a Novel First-in-Class Analgesic.N/OFQ system in brain areas of nerve-injured mice: its role in different aspects of neuropathic pain.Targeting multiple opioid receptors - improved analgesics with reduced side effects?In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain.Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain.In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403.Cebranopadol, a novel first-in-class analgesic drug candidate: first experience in patients with chronic low back pain in a randomized clinical trial.Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?Understanding the Agent, Part I: Opioid Biology and Basic PharmacologyNociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic
P2860
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P2860
Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Functional plasticity of the N ...... rties of NOP receptor agonists
@ast
Functional plasticity of the N ...... rties of NOP receptor agonists
@en
Functional plasticity of the N ...... rties of NOP receptor agonists
@nl
type
label
Functional plasticity of the N ...... rties of NOP receptor agonists
@ast
Functional plasticity of the N ...... rties of NOP receptor agonists
@en
Functional plasticity of the N ...... rties of NOP receptor agonists
@nl
prefLabel
Functional plasticity of the N ...... rties of NOP receptor agonists
@ast
Functional plasticity of the N ...... rties of NOP receptor agonists
@en
Functional plasticity of the N ...... rties of NOP receptor agonists
@nl
P2860
P50
P3181
P356
P1476
Functional plasticity of the N ...... rties of NOP receptor agonists
@en
P2093
P2860
P304
P3181
P356
10.1111/BPH.12744
P407
P577
2014-08-01T00:00:00Z