about
Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivityBiased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonistsLigand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor.[EXPRESS] Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats.Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin AIntrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future.Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and PathologyMorphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.Themed section.How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways.Conformational Heterogeneity of Intracellular Loop 3 of the μ-opioid G-protein Coupled Receptor.Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor.Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation.A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.Computational insights into the G-protein-biased activation and inactivation mechanisms of the μ opioid receptor.Better agonist for the opioid receptors.Hydrocodone is More Effective than Morphine or Oxycodone in Suppressing the Development of Burn-Induced Mechanical Allodynia.The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception.Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.Attenuating the Agent: Reducing Opioid “Virulence”
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Novel GPCR paradigms at the μ-opioid receptor
@ast
Novel GPCR paradigms at the μ-opioid receptor
@en
Novel GPCR paradigms at the μ-opioid receptor
@nl
type
label
Novel GPCR paradigms at the μ-opioid receptor
@ast
Novel GPCR paradigms at the μ-opioid receptor
@en
Novel GPCR paradigms at the μ-opioid receptor
@nl
prefLabel
Novel GPCR paradigms at the μ-opioid receptor
@ast
Novel GPCR paradigms at the μ-opioid receptor
@en
Novel GPCR paradigms at the μ-opioid receptor
@nl
P2860
P356
P1476
Novel GPCR paradigms at the μ-opioid receptor
@en
P2093
P2860
P304
P356
10.1111/BPH.12600
P407
P577
2015-01-01T00:00:00Z