Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development - sprookjes - yvandenbroek - TriplyDB

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

http://www.wikidata.org/entity/Q26997109

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Aberrant Wnt Signaling in Leukemia Research progress in the radioprotective effect of the canonical Wnt pathway Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells Decreased SFRP2 expression is associated with intermediate and poor karyotypes in de novo acute myeloid leukemia Signalling pathways that control vertebrate haematopoietic stem cell specification.Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Notch signalling inhibits CD4 expression during initiation and differentiation of human T cell lineage.The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation.Myelodysplasia is in the niche: novel concepts and emerging therapies.Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/β-catenin signaling pathway.An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in acute myeloid leukemia.A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia.Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling Using bioinformatic approaches to identify pathways targeted by human leukemogens PTH expands short-term murine hemopoietic stem cells through T cells γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B.Regulation of endothelial progenitor cell release by Wnt signaling in bone marrow.Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.β-Catenin induces T-cell transformation by promoting genomic instability.Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling.Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches.B-lineage transcription factors and cooperating gene lesions required for leukemia development.Wnt signaling in leukemias and myeloma: T-cell factors are in control.Epigenetics of myelodysplastic syndromes.Wnt/β-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4.RNA interference for multiple myeloma therapy: targeting signal transduction pathways.Wnt/β-catenin signaling in bone marrow niche.Hypoxia regulates the hematopoietic stem cell niche.Blockage of Wnt/β-Catenin Signaling by Nanoparticles Reduces Survival and Proliferation of CLL Cells In Vitro-Preliminary Study.On signaling pathways: hematopoietic stem cell specification from hemogenic endothelium.The functional relationship between hematopoietic stem cells and developing T lymphocytes.The Wnt signaling pathway in cancer.Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.Wnt signaling inhibitor FH535 selectively inhibits cell proliferation and potentiates imatinib-induced apoptosis in myeloid leukemia cell lines.Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development.

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Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

http://www.wikidata.org/entity/Q26997109

description

2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年論文

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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Wnt signaling strength regulat ...... volved in leukemia development

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F J T Staal

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

High bone density due to a mutation in LDL-receptor-related protein 5

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

Wnt-3a regulates somite and tailbud formation in the mouse embryo

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

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10.1038/LEU.2011.387

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