The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
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Inhibitors of Ras-SOS Interactions.The Role of Allostery in the Termination of Second Messenger Signaling.A New View of Ras Isoforms in Cancers.Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene.The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.Cancer stem cell drugs target K-ras signaling in a stemness context.PRKAR1A is a functional tumor suppressor inhibiting ERK/Snail/E-cadherin pathway in lung adenocarcinoma.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.Intrinsic protein disorder in oncogenic KRAS signaling.Independent and core pathways in oncogenic KRAS signaling.Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding.Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains.The dynamic mechanism of RASSF5 and MST kinase activation by Ras.Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells.Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics.
P2860
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P2860
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
description
2015 nî lūn-bûn
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2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@ast
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@en
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@nl
type
label
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@ast
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@en
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@nl
prefLabel
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@ast
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@en
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@nl
P2093
P2860
P3181
P1476
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
@en
P2093
Chung-Jung Tsai
Hyunbum Jang
Ozlem Keskin
Ruth Nussinov
Serena Muratcioglu
P2860
P304
P3181
P356
10.1158/1541-7786.MCR-15-0165
P407
P577
2015-06-17T00:00:00Z