The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment - sprookjes - yvandenbroek - TriplyDB

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

http://www.wikidata.org/entity/Q27025661

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Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics YAP-Mediated Mechanotransduction in Skeletal Muscle Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis Dynamic self-guiding analysis of Alzheimer's disease.YAP and TAZ: a nexus for Hippo signaling and beyond Hippo/YAP pathway for targeted therapy MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies.The Hippo signaling pathway in stem cell biology and cancer Expression of Yes-associated protein 1 and its clinical significance in ovarian serous cystadenocarcinoma Lung epithelial stem cells and their niches: Fgf10 takes center stage.Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells.YAP determines the cell fate of injured mouse hepatocytes in vivo.Yes-Associated Protein Expression Is Correlated to the Differentiation of Prostate Adenocarcinoma.The Hippo pathway in disease and therapy: cancer and beyond Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces.A gp130-Src-YAP module links inflammation to epithelial regeneration.Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

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description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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The two faces of Hippo: target ...... medicine and cancer treatment

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The two faces of Hippo: target ...... medicine and cancer treatment

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Nature Reviews Drug Discovery

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The two faces of Hippo: target ...... medicine and cancer treatment

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Randy Johnson

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TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

Physical interaction with Yes-associated protein enhances p73 transcriptional activity

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

Yap1 acts downstream of α-catenin to control epidermal proliferation

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

PTPN14 is required for the density-dependent control of YAP1

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

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