about
CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo.Safety and preliminary efficacy data of a novel casein kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies.Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models.Bio-analytical method based on MALDI-MS analysis for the quantification of CIGB-300 anti-tumor peptide in human plasma.Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor.Mechanisms of cellular uptake, intracellular transportation, and degradation of CIGB-300, a Tat-conjugated peptide, in tumor cell lines.Sensitivity of tumor cells towards CIGB-300 anticancer peptide relies on its nucleolar localization.CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research.Proteomic profile regulated by the anticancer peptide CIGB-300 in non-small cell lung cancer (NSCLC) cells.Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity.Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice.CIGB-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo
P921
Q33346339-642F5A5B-D6BA-4B3A-B92C-DEE5FE93539AQ33445369-64A68A22-5D04-468B-B798-08D653B2C8D2Q34265716-719CCA51-4AAC-4DC3-AA18-E2DD34EC8285Q35535114-45851BC8-3EE0-46EA-9E5A-4943CBD88BE9Q38365378-7B37EF65-93FA-4B4F-900E-DD08DE97C40FQ39000756-0CA6DFF8-82D2-4AD2-A1CE-A07091C3392DQ39381625-F74020CB-41C9-4B14-9D48-FC0A9A47E056Q39511426-6AE525B5-700F-4204-99BE-A2114335F4E0Q39661789-D73189C9-8BDF-4CEC-80BF-27E3B984E00DQ39856347-7E699BB7-E2F0-46E2-901D-64B08BB7F4A6Q40082517-864354D0-BC66-454D-8802-7ED86D28369BQ84084216-94342F06-0A0C-4277-8093-BE85E309493E
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
CIGB-300
@en
type
label
CIGB-300
@en
altLabel
P15-tat
@en
prefLabel
CIGB-300
@en
P661
P662
P683
P1579
P2067
P233
CC(C)CC1C(=O)NCC(=O)NC(C(=O)NC ...... CNC(=N)N)NC(=O)CN)C(=O)O)C(C)O
P235
RNELHWXSRSKXRD-QNKYCTLBSA-N
P274
C₁₂₇H₂₁₅N₅₃O₃₀S₃